Effectiveness of children and adolescents’ rehabilitation from environmentally disadvantaged areas of the Voronezh region, under a local sanatorium terms.

Title: Effectiveness of children and adolescents’ rehabilitation from environmentally disadvantaged areas of the Voronezh region, under a local sanatorium terms.

Author: Aphanasenko, Lyudmila Kuzminichna

Reference: Voronezh, 2006

Keywords: rehabilitation, screening, children, adolescents, sanatorium treatment, morbidity, immune system, Voronezh Region

Abstract: Research aim: to improve the rehabilitation activities of children and adolescents who live in the Voronezh region with preferential socio-economic status under a local sanatorium terms.

URL:http://www.dissercat.com/content/effektivnost-reabilitatsii-detei-i-podrostkov-iz-ekologicheski-neblagopriyatnykh-raionov-vo-0

Ultrasonic diagnosis of thyroid pathology in children exposed to radiation as a result of the Chernobyl accident

Title: Ultrasonic diagnosis of thyroid pathology in children exposed to radiation as a result of the Chernobyl accident

Author: Drozd Valentina Mikhailovna

Reference:

doi:

Keywords: thyroid gland, ultrasonic diagnosis, child’s age, screening, dosimetry, morphology of thyroid cancer.

Abstract: 6895 children and adolescents aged 4 to 17 years from contaminated areas of Gomel, Mogilev and Brest region (6383) and control Braslav district of Vitebsk region were studied.

The goal of present investigation was to elaboration of complex program of early detection of thyroid pathology in children and improving, on its basis, of clinical and sonomorphological criteria of topical and nosological diagnostics.

As a result of performed investigation improved method of thyroid sonography has been worked out and introduced into clinical practice. This software method allows to reveal thyroid pathology at an early stage in 50-100% of patients, to form risk groups, to effectively select patients for surgery, to carry out dynamic control of carcinoma and to reveal thyroid cancer recurrences.

During ultrasonic screening of children from Khoiniky region an increased prevalence of different changes of thyroid ultrasonic picture including thyroid cancer was revealed compared to control region.

A significant increase in thyroid hyperplasia, changes of thyroid ultrasonic pictures, characteristic of endemic areas were found during repeated screening.

Peculiarities of ultrasonic picture in main forms of thyroid pathology in children were revealed and described. According to ultrasonic data nodular and diffuse forms of thyroid cancer were classified, one of the possible reasons for relatively high incidence of extrathyroid spread of thyroid cancer could be both aggressive behaviour of tumour and its close to capsule location.

Practical recommendations for early diagnosis and adequate follow-up of patients with thyroid pathology have been worked out.

http://medical-diss.com/medicina/ultrazvukovaya-diagnostika-patologii-schitovidnoy-zhelezy-u-detey-podvergshihsya-radiatsionnomu-vozdeystviyu-v-rezultate–

Medical screening of thyroid diseases in the Gomel region, Belarus

Title: Medical screening of thyroid diseases in the Gomel region, Belarus
Author: Vorobey, Vladimir S / Masyakin, Vladimir B / Arkhipenko, Vladimir N / Panasyuk, Galina D / Derzhitskaya, Yelena V / Batalova, Yelena N

Reference: International Congress Series, 1234, p.49-55, May 2002

doi: 10.1016/S0531-5131(01)00594-5

Keywords: Medical screening; Thyroid diseases; Belarus

Abstract: …been observed in thyroid cancer among children…contribution of the Chernobyl-Sasakawa Project…diagnosis of thyroid cancer among children and…period of the Chernobyl-Sasakawa International…Approximately 16% of thyroid cancer cases among children…

URL: http://www.sciencedirect.com/science/article/pii/S0531513101005945

Molecular epidemiology of childhood thyroid cancer around Chernobyl

Title: Molecular epidemiology of childhood thyroid cancer around Chernobyl

Author: Yamashita, Shunichi / Shibata, Yoshisada / Namba, Hiroyuki / Takamura, Noboru / Saenko, Vladimir,

Reference: International Congress Series, 1236, p.201-205, Jul 2002

doi: 10.1016/S0531-5131(01)00855-X

Keywords: Chernobyl; Screening ; Thyroid cancer; Gene rearrangement; Signal transduction

Abstract: …The comparative study of thyroid diseases demonstrates the likelihood of short-lived radioactive iodine on thyroid cancer in the children born before the Chernobyl accident. Next, at the standpoint of recent molecular analysis of thyroid carcinogenesis, many reports now indicate evidence of a high incidence of ret/PTC gene rearrangement in childhood thyroid cancer tissues. Besides ret/PTC gene rearrangement, the disturbance of the response of intracellular signal transduction to radiation exposure is also important in thyroid cells, and results demonstrate that radiation exposure could cause abnormal thyroid cell proliferation specifically through constitutive activation of intracellular target molecules via membrane lipid breakdown, and subsequently disturb the apoptosis-prone pathway. …Therefore, the late effect of radiation, even in the lower dose on the human thyroid glands, should be monitored carefully for the radiation-sensitive vulnerable group for a longer period, especially around Chernobyl.

URL: http://www.sciencedirect.com/science/article/pii/S053151310100855X