Clinical and laboratory criteria to evaluate the adaptive-regulatory system of liquidators of the Chernobyl accident in remote period
Author: L.B. Drygina
Reference: Dissertation, doctor of biology, St. Petersburg, 2002
Keywords: hormonal homeostasis, liquidator, euron-specific enolase, thyroglobulin, SA 19-9, carcinoembryonic antigen
Abstract: Relationship of parameters of thyroid autoimmunity and hormonal homeostasis, allowing to predict the tendency to nodulation and hormone-genesis change in the thyroid glands of liquidators is shown. In male liquidators a complex clinical and laboratory screening, of osteotropic level, of hormones in the blood serum, was made, to examine the production of proinflammatory cytokines, indicators of mineral homeostasis, and biochemical markers of bone remodeling, revealing the state of the musculoskeletal system after exposure to complex factors of a radiation accident. Comparative analysis of the frequency of cancer in male liquidators, after long time of the accident, with the results of the study of tumor-associated antigens in peripheral blood, is shown to be effective in monitoring the neuron-specific enolase (NSE), thyroglobulin (TG), SA 19-9 and carcinoembryonic antigen (CEA). …
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