Chromosomal aberrations, micronuclei and apoptosis in lymphocytes under radiation effects and other pathological conditions

Author: KOLYUBAEVA Svetlana Nikolaevna

Reference: Article, Obninsk, Russia, 2010

Abstract: Purpose of the study: to conduct clinical and experimental studies to evaluate genome damage of lymphocytes under development of pathological conditions caused by exposure to radiation in comparison with other damaging factors.

Subject of the present research are:

1. To study the frequency of chromosomal aberrations (CA) and micronuclei (MN) in peripheral blood lymphocytes after exposure in vitro.

2. To determine the dependence of induction of apoptotic lymphocytes by irradiation, using samples of human blood in vitro and experiments of laboratory animals in vivo.

3. To identify the dose dependence of stable CA in humans and monkeys by fluorescence in situ hybridization (FISH).

4. To investigate the effect of irradiation on the level of CA and MN in patients with impaired thyroid homeostasis. etc.

URL: http://earthpapers.net/hromosomnye-aberratsii-mikroyadra-i-apoptoz-v-limfotsitah-pri-radiatsionnyh-vozdeystviyah-i-drugih-patologicheskih-sostoy

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