カテゴリー「cancer」
Title: Population patterns of development at oncopathology population living in contaminated areas after the Chernobyl accident
Author: Parshkov E. M., Sokolov V. A., Golivets T. P., Kovalenko B. S., Artamonova YU. Z.
Reference: 2009 year, VAK speciality — 14.00.00, author —
Keywords: The Chernobyl accident, Oncology, population incidence, descriptive epidemiological analysis, mechanisms of carcinogenesis, Belgorod and Bryansk area
Abstract: Descriptive epidemiological analysis of more than 200 thousands of new cancer cases over 25-year period (1981-2005) among population of the Belgorod and Bryansk Regions affected as a result of the Chernobyl accident was carried out. Age-gender dependencies of population oncopathology development during this period as well as the dynamics the incidence changes in separate nosological units were determined. It was shown that exposure in low dose after the Chernobyl accident led to wavy change of the incidence with the period 5-7 years and that radiation-induced incidence developed in the format of spontaneous one. The role of physiological factors of organism and processes of cell proliferation and differentiation in cancer development are discussed.
URL: http://cyberleninka.ru/article/n/polovozrastnye-zakonomernosti-razvitiya-onkopatologii-u-naseleniya-prozhivayuschego-na-zagryaznennyh-territoriyah-posle#ixzz3rHTGEqFR
Title: Oncoepidemiologic situation on the territory of the Kaluga region 10 years after the Chernobyl accident
Author: Ivanov V.K., Nilova E.V., Efendiev V.A.*, Gorsky A.I., Pitkevich V.A., Leshakov S.Y.*, Shiryaev V.I.
Reference:”Questions of oncology”1997 vol.43, No.2
Keywords:
Abstract: Medical Radiological Research Centre of RAMS, Obninsk; * – Department of Health, Administration of Kaluga Region, Kaluga Cancer morbidity and mortality has been studied in the contaminated areas of the Kaluga region. The objective of the study was to evaluate to what extent the radiation factor has influenced the existing levels of cancer morbidity and mortality. Analysis was performed of standardized ratios of cancer incidence and mortality and corresponding population risks. The conclusion based on the analysis suggests that the current incidence rates of malignant neoplasms in the population of the studied areas affected by the Chernobyl accident were formed under the influence of a number of factors which showed themselves before the accident. Of particular concern are the trends noticed in oncoepidemiologic processes in the Uly-anovsky district of the region. Thus far no statistically reliable effect of the radiation factor on cancer incidence (except thyroid cancer in the female population of the contaminated areas) has been detected. The cancer morbidity and mortality in the contaminated areas are largely in agreement with the general indicators throughout the region. By and large the drawn conclusion is consistent with data of the world practice on latent periods in inducing radiogenic cancers and extent of biological effects for the irradiation levels to which the population on the contaminated areas is exposed.
URL: http://refereed.ru/ref_810b5710d655a3c837fb6cf8d098fe88.html
Title: Micronuclei in lymphocytes of children from the vicinity of Chernobyl before and after 131I therapy for thyroid cancer
Author: Wuttke K, Streffer C, Müller WU, Reiners C, Biko J, Demidchik E.
Reference: 1996, Vol. 69, No. 2 , Pages 259-268
doi: 10.1080/095530096146101
Keywords :
Abstract: The present study addresses the monitoring of children from the Belorussian and Ukrainian Republics exposed to the fall-out of the Chernobyl accident. Micronucleus analysis has been performed on 56 children from different areas. The micronucleus frequencies in individuals as well as in regional groups were comparable with controls, except for three donors. Such results had to be expected, taking into account that at least 7 years have passed since the accident. Most of the children whose micronucleus frequencies were determined are suffering from thyroid cancer and were treated by radioiodine (131I) therapy. We studied the effect of in vitro exposure with 131I on micronucleus induction and that proliferative ability of lymphocytes. The present investigation indicates that micronuclei can be usefully employed to detect individual exposures to the incorporated radionuclide within several days after the intake of the radionuclide in a dose range of around 65-390 mGy (effective dose).
ＵＲＬ: http://www.ncbi.nlm.nih.gov/pubmed/8609463
Title: Childhood leukemia in Belarus before and after the Chernobyl accident
Author: E. P. Ivanov, G. V. Tolochko, L. P. Shuvaeva, S. Becker, E. Nekolla, A. M. Kellerer
Reference: Radiation and Environmental Biophysics, Volume 35, Issue 2 , pp 75-80
doi: 10.1007/BF02434028
Keywords : leukemia, Belarus
Abstract: Childhood leukemia (ICD 204–208 [1]) incidence rates in the different regions of Belarus are reported for a period before and after the Chernobyl accident (1982–1994). There are, at this point, no recognizable trends towards higher rates.
ＵＲＬ: http://link.springer.com/article/10.1007/BF02434028
Title: Microvessel density is high in clear-cell renal cell carcinomas of Ukrainian patients exposed to chronic persistent low-dose ionizing radiation after the Chernobyl accident
Author: A. M. Romanenko, A. Ruiz-Saurí, L. Morell-Quadreny, G. Valencia, A. F. Vozianov, A. Llombart-Bosch
Reference: Virchows Archiv , June 2012, Volume 460, Issue 6, pp 611-619
DOI: 10.1007/s00428-012-1243-x
Keywords : Conventional renal cell carcinoma, Ionizing radiation, Angiogenesis, Microvessel density, CD31antibody
Abstract: During the 25-year period subsequent to the Chernobyl accident, the morbidity of malignant renal tumors in Ukraine has increased from 4.7 to 10.7 per 100,000 of the total population. Recent studies of our group have shown that increases in morbidity, aggressiveness, and proliferative activity of renal cell carcinomas (RCCs), especially clear-cell renal cell carcinoma (CCRCC), in Ukrainian patients continuously inhabiting the radio-contaminated areas could be explained by specific molecular changes influenced by the so-called “chronic persistent low-dose ionizing radiation” (CPLDIR) exposure. This study aimed to examine the role of angiogenesis in CCRCC carcinogenesis associated with CPLDIR in patients living more than 20 years in cesium 137 (137Cs) contaminated areas after the Chernobyl accident in Ukraine. Paraffin-embedded specimens of 106 CCRCs were studied: Control cases were 18 tumors from Spanish patients (group 1), 25 tumors from Ukrainian patients from so-called clean areas without known radio-contamination (group 2), and 63 tumors from Ukrainian patients from radio-contaminated areas (group 3).
URL：http://link.springer.com/article/10.1007/s00428-012-1243-x
Title: Medical radiological consequences of the Chernobyl catastrophe in Russia: estimation of radiation risks.
Author: V. Ivanov, A. Tsyb, S. Ivanov, V. Pokrovsky
Reference: – St. Petersburg: Nauka, 2004. – 388 p.
Keywords:
Abstract: The monograph is devoted to estimation of medical radiological effects of the Chernobyl disaster for emergency workers and the population of Russia.
Based on analysis of the radiation and environmental situation in the contaminated territories and estimates of radiation doses, incidence of cancer diseases among emergency workers and the population due to the postchernobyl exposure has been predicted. For the cohort of emergency workers estimation of radiation risks of non-cancer diseases is also discussed.
Consideration is given to estimates of risks of solid cancers, first-time thyroid cancer and leukemias derived in the radiation epidemiological studies of actual data available in the Russian National Medical and Dosimetric Registry.
The work is intended for environmental scientists, radiation epidemiologists, radiobiologists, specialists in medical radiology and radiation protection.
URL: http://www.nrer.ru/monograf.html
Title: The latent period of induction radiogennyh of solid cancers in a cohort of liquidators
Author: Gorskiy A.I., Kascheev V.V., Tumanov K.A.
Reference: Radiation and Environmental Biophysics, Volume 48, Number 3 / August 2009, pp 247-252
Keywords: emergency workers ,latent period ,solid tumors ,Radiation risk
Abstract: The paper presents results of estimating the latent period of induction of radiogenic solid cancers among Chernobyl emergency workers (males) living in six central regions of Russia. The analysis is based on using medical and dosimetry data gathered by the National Radiation Epidemiological Registry (NRER) over the time period from 1986 to 2005. The cohort size is 59706 persons. These are emergency workers who stayed in the exposure zone in 1986-1987. There were 2562 cases of solid tumors detected during the follow-up time in this cohort. The mean radiation dose is 0.13 Gy. The radiation risk and latent period were estimated using the method of maximum likelihood. The excess relative risk per unit dose was found to be 0.92 (0.28; 1.65 95 % CI) and the minimum latent period of induction of solid tumors is 4.7 years (1.2; 9.4 95 % CI).
URL: http://www.nrer.ru/pub_results.html
Title: Radiation injury to human body: atomic bombs, Chernobyl and Fukushima
Author: Masao TOMONAGA
Reference: Rinsho Ketsueki, Vol. 52 (2011) No. 10 P 1740-1747
DOI: http://dx.doi.org/10.11406/rinketsu.52.1740
Keywords: Deterministic effect, Stochastic effect, Acute radiation syndrome, Radiation-induced leukemia, Chernobyl , Fukushima
ＵＲＬ：https://www.jstage.jst.go.jp/article/rinketsu/52/10/52_10_1740/_article/-char/ja/
Keywords: Radiobiology, monitoring, oncological pathology
Abstract: The aim is to develop and test methodology for monitoring cancer incidence (mortality) to identify possible carcinogenic effects of radiation (environmental) factors on health of the population on thebases of the current Russian system of registration of cancer and demographic processes.
URL:http://www.referun.com/n/metodologiya-monitoringa-kantserogennyh-effektov-vozdeystviya-radiatsionnogo-ekologicheskogo-faktora-na-naselenie
Author: BOLOHONENKOVA, M.A.
Reference: Article, Obninsk, 03.00.01
Keywords: Radiobiology, liquidators
Data of the National Radiation and Epidemiological Registry (NRER) and results of sample analyses of sanatorium card of liquidators have served as the basis of the present analysis.
URL: http://earthpapers.net/kontrol-kachestva-registratsii-zabolevaemosti-uchastnikov-likvidatsii-posledstviy-avarii-na-chaes-v-razlichnyh-dozovyh-gr
