カテゴリー「pediatrics」
Title:Post-chernobyl thyroid carcinoma in Belarus children and adolescents: Comparison with naturally occurring thyroid carcinoma in Italy and France
Author:Pacini Furio, Vorontsova Tatiana, Demidchik Eugeni P., Molinaro Eleonora, Agate Laura, Romei Cristina, Shavrova Elena, Cherstvoy Eugeny D., Ivashkevitch Yuriy, Kuchinskaya Elvira, Schlumberger Marin, Ronga Giuseppe, Filesi Mauro, Pinchera Aldo
Reference: J. Clin. Endocrinol. and Metab. N 11, 1997, т.82, стр.3563-3569
URL: http://sci-pub.info/ref/340925/
Title: High prevalence of RET rearrangement in thyroid tumors of children from Belarus after the Chernobyl reactor accident
Author:Klugbauer S., Lengfelder E., Demidchik E.P., Rabes H.M.
Reference:Oncogene N 12, 1995, т.11, стр.2459-2467
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Title: Condition of peripheral blood system in children and adolescents, who are living in radiated polluted area (study in 10 years after Chernobil accident).
Author: Dubey L.Ya.
Reference: 14.01.310 – pediatria. – Kharkov state Medical University, the Ministry of Public Health, Kharkov, 2001.
Key words: children, adolescents, peripheral blood system, inner radiation, environment pollution.
Annotation:This work is devoted to a problem of influence of low doses radiations on peripheral blood in children and adolescents, who are living in northern areas of Zhitomir region.The conditions of children’s health, who are living in radiated polluted area was studied. Children’s deaseses at postaccident period was investigated. Total and characteric changes of health conditions due to low doses radiations was determined. The epidemiology of inner radiation toward incorporation radiocezium level was studied. Different inner radiation doses influence on blood system was investigated.Peripheral blood conditions data in children and adolescents due to radiated polluted environment and tot al inner radiotions activity was determined. The correlative analisis of different peripheral blood data in children and adolescents due to the level of` inner radiotions density activity was performed.
Title: Micronuclei in lymphocytes of children from the vicinity of Chernobyl before and after 131I therapy for thyroid cancer
Author: Wuttke K, Streffer C, Müller WU, Reiners C, Biko J, Demidchik E.
Reference: 1996, Vol. 69, No. 2 , Pages 259-268
doi: 10.1080/095530096146101
Keywords :
Abstract: The present study addresses the monitoring of children from the Belorussian and Ukrainian Republics exposed to the fall-out of the Chernobyl accident. Micronucleus analysis has been performed on 56 children from different areas. The micronucleus frequencies in individuals as well as in regional groups were comparable with controls, except for three donors. Such results had to be expected, taking into account that at least 7 years have passed since the accident. Most of the children whose micronucleus frequencies were determined are suffering from thyroid cancer and were treated by radioiodine (131I) therapy. We studied the effect of in vitro exposure with 131I on micronucleus induction and that proliferative ability of lymphocytes. The present investigation indicates that micronuclei can be usefully employed to detect individual exposures to the incorporated radionuclide within several days after the intake of the radionuclide in a dose range of around 65-390 mGy (effective dose).
ＵＲＬ: http://www.ncbi.nlm.nih.gov/pubmed/8609463
Title: Micronucleus formation in lymphocytes of children from the vicinity of Chernobyl after 131I therapy
Author: W.-U. Müller, S. Dietl, K. Wuttke, C. Reiners, J. Biko, E. Demidchik, C. Streffer
Reference: Radiation and Environmental Biophysics , May 2004, Volume 43, Issue 1, pp 7-13
doi: 10.1007/s00411-004-0233-z
Keywords : Lymphocytes, children, Iodine-131, thyroid tumours
Abstract: After the Chernobyl accident a statistically significant increase in the number of children with thyroid tumours was observed. In this study 166 children with and 75 without thyroid tumours were analysed for micronucleus formation in peripheral blood lymphocytes using the cytochalasin B approach. The following factors did not significantly affect micronucleus formation: gender, age at the time of the first 131I treatment, tumour stage, tumour type, or metastases; a statistically significant increase in the number of micronuclei, however, was observed for the residents of Gomel compared to other locations, such as Brest, Grodno, and Minsk. The children with tumours received 131I treatment after surgical resection of the tumours. This gave us the opportunity to systematically follow the effect of 131I on micronucleus formation. A marked increase was observed 5 days after the 131I treatment followed by a decrease within a 4–7 months interval up to the next application, but the pre-treatment levels were not achieved. Up to 10 therapy cycles were followed each including an analysis of micronucleus formation before and 5 days after 131I application. The response of the children was characterised by clear individual differences and the increase/decrease pattern of micronucleus frequencies induced by iodine-131 was correlated with a decrease/increase pattern in the number of lymphocytes.
ＵＲＬ: http://link.springer.com/article/10.1007/s00411-004-0233-z
Title: Tissue reactions under chronic exposure to ionizing radiation
Author: A. V. Akleyev
Reference: Biophysics, February 2010, Volume 55, Issue 1, pp 128-141
DOI: 10.1134/S0006350910010203
Keywords : chronic exposure, hemopoiesis, immunity, endocrine system, gonads, skin, lungs
Abstract: Reviewed are radiobiological data on the emergence of tissue reactions that may determine the course and outcome of human chronic irradiation. The main mechanisms of the reaction of hemopoietic, immune, reproductive, endocrine, respiratory systems and skin to long-term and fractionated exposure to ionizing radiation are considered. The problem of developing a new approach to threshold dose estimation for chronic exposure effects is discussed.
ＵＲＬ：http://link.springer.com/article/10.1134%2FS0006350910010203
Title: Analysis of Blood Lymphocyte Subsets in Children Living around Chernobyl Exposed Long-Term to Low Doses of Cesium-137 and Various Doses of Iodine-131
Author: Eugene V. Vykhovanets, Victor P. Chernyshov, Igor I. Slukvin, Yury G. Antipkin, Alexander Vasyuk, and Valerey Colos
Reference: Radiation Research June 2000 : Vol. 153, Issue 6 (Jun 2000), pg(s) 760-772
DOI: http://dx.doi.org/10.1667/0033-7587(2000)153[0760:AOBLSI]2.0.CO;2
Keywords : blood lymphocyte, children, low doses, cesium-137, iodine-131
Abstract: Epidemiological studies have found that children living around Chernobyl have rates of respiratory tract illness that are higher than those seen in the area before the Chernobyl accident. The present study investigates the possible effects of radiation exposure on the composition of peripheral blood lymphocyte subsets in children living around Chernobyl. Two hundred nineteen healthy children and children suffering from recurrent respiratory diseases aged 6–14 years who received both low doses of radiation to the whole body from 137Cs and various doses of radiation to the thyroid from 131I as fallout from the accident were assessed 5 (1991) and 8–10 years (1994–1996) after the accident. A total of 148 healthy children and children suffering from recurrent respiratory diseases living in noncontaminated areas were also evaluated as controls. Children with recurrent respiratory diseases who lived around Chernobyl had a significantly lower percentage of T cells and a higher percentage of NK cells compared to control children with recurrent respiratory diseases during the study period. In contrast to the findings in 1991, a significant decrease in the percentage of helper-inducer cells was observed in children with recurrent respiratory diseases in 1994–1996. In contrast to 1991, there is a positive correlation between the percentage of helper-inducer cells, the helper-inducer/cytotoxic-suppressor cell ratio, and the dose of radiation to the thyroid of healthy children from 131I in 1994–1996. There was a positive correlation between the dose of radiation to the thyroid from 131I and the percentage of helper-inducer cells in children with recurrent respiratory diseases 5 years (1991) after the accident. Further, the dose of radiation to the thyroid from 131I correlated negatively with the percentage of T and B cells and positively with the percentage of NK cells in children with recurrent respiratory diseases 8–10 years (1994–1996) after the accident. These results raise the possibility that long-term exposure to low doses of 137Cs may have altered the composition of the T-cell subsets and NK cells in children with recurrent respiratory diseases. The differences in the composition of the peripheral blood lymphocyte subsets between healthy children and those with recurrent respiratory diseases may be attributed to long-term low-dose exposure of the whole body to radiation from 137Cs and exposure of the thyroid to radiation from 131I subsequent to the Chernobyl accident.
ＵＲＬ：http://www.bioone.org/doi/abs/10.1667/0033-7587%282000%29153%5B0760%3AAOBLSI%5D2.0.CO%3B2?prevSearch=chernobyl%2Bobstetrics&searchHistoryKey=&queryHash=93d611a9bfec5beb1e2f82cb49cf110e
