Chernobyl, radiation and thyroid cancer

Title: Chernobyl, radiation and thyroid cancer

Author: Williams, Dillwyn

Reference: International Congress Series, 1299, p.219-224, Feb 2007

doi: 10.1016/j.ics.2006.10.020

Keywords: Chernobyl; Radiation; Thyroid cancer; Latency; Mutation; Sensitivity

Abstract: The effects of radiation on man have been largely based on atomic bomb studies, Chernobyl exposure differs in radiation type, dose rate and tissue distribution. This review analyses the way in which Chernobyl studies have altered our understanding of radiation and thyroid carcinoma. Latency for radiation-related thyroid carcinoma is not fixed at 10 years; the time of detection of the first cases depends on the size of the outbreak. Radioiodine is not of low carcinogenicity, it is an effective thyroid carcinogen for young children for explicable reasons. Clinical, morphological and molecular studies after Chernobyl show a correlation with tumour latency, with short latency tumours largely showing RET PTC3 rearrangements, a solid type of papillary carcinoma and an aggressive clinical behaviour. …

URL: http://www.sciencedirect.com/science/article/pii/S0531513106006224

キーワードタグ

前後へのリンク