Comparative Morphological Analysis of Papillary Thyroid Carcinoma in Children and Adolescents Born before and after Chernobyl Accident
Title: Comparative Morphological Analysis of Papillary Thyroid Carcinoma in Children and Adolescents Born before and after Chernobyl Accident
Author: Abrosimov A. Yu.
Reference: Medical Radiological Research Center of Russian Academy of Medical Sciences, 4 Korolev str., Obninsk, Kaluga district, 249036 Russia
ISSN: 0025-8334
Keywords: THYROID, RADIOGENIC AND SPORADIC PAPILLARY CARCINOMA, CHILDREN AND ADOLESCENTS, CHERNOBYL ACCIDENT
Abstract: Purpose: To elaborate comparative morphological analysis of radiogenic and sporadic papillary thyroid carcinoma in children and adolescents bom before and after Chernobyl accident and living in the radionuclide contaminated regions of the Russian Federation. Material and methods: Histological sections of papillary carcinoma and medical records from I8O children (under 15 years old) and adolescents (from 15 to 19 years) living in Bryansk, Kaluga, Oryol and Tula regions of Russia have been examined. The first group of radiogenic cancer cases includes 130 patients whose thyroid might be exposed after the accident. The second group of sporadic tumors includes 50 patients bom since the end of January 19S7 and whose thyroid exposure to radioiodine becomes negligible. A comparison between two groups via prevalence of different histological types of papillary carcinoma and other morphological features of tumor growth has been performed. Results;The male/female ratio in the first group is 1/1.5 comparing to the second group where it is 1/3.2. The average size of tumors in the first group is higher than that in the second one (14.6+1.0 mm vs. 11.4+0.8 mm), but difference is not quite significant (p-0.06). The differences between higher extent of tumor stromal fibrosis (52.3 %) and extent of cxtrathyroid invasion (23.8 %) of tumors in the first group comparing to the second group (28.0 % and 8.0 % respectively) are statistically significant (p<0.01 and р=0.02 respectively). No differences ‘between two groups have been revealed in the prevalence of various histological types of papillary carcinoma. Conclusion: Radiogenic and sporadic papillary carcinomas have no specific types of histological architecture (histological variants). Twо groups differ from each other by the male/female ratio (females are significantly prevailing in the sporadic group), as well as by the extent of stromal fibrotic response and extent of extrathyroid invasive growth that could be revealed more often in the group of radiogenic papillary thyroid carcinomas.
URL: http://elibrary.ru/item.asp?id=10019508
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