Dose response for T-cell receptor (TCR) mutants in patients repeatedly treated with 131 I for thyroid cancer

Title: Dose response for T-cell receptor (TCR) mutants in patients repeatedly treated with 131 I for thyroid cancer
Author: Vershenya, Stanislav / Biko, Johannes / Drozd, Valentina / Lorenz, Reinhard / Reiners, Christoph / Hempel, Klaus

Reference: Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 548 (1-2), p.27-33, Apr 2004

doi: 10.1016/j.mrfmmm.2003.12.015

Keywords: T-cell receptor; Mutation; Radiation; Thyroid cancer; Chernobyl

Abstract: The T-cell receptor mutant frequency (TCR-Mf) was measured in 53 young adults, who were treated with radioiodine for thyroid cancer. Patients came from the southern part of Belarus. This region had suffered the most from the Chernobyl Disaster. TCR-Mf was determined by flow cytometry before and after 1 to maximal 10 treatments. Before treatment, TCR-Mf of patients was 2.0×10⁻⁴. This Mf value is in the same range as that of young healthy students. After radioiodine therapy (RIT), TCR-Mf increases within about half a year to a maximum…

URL: http://www.sciencedirect.com/science/article/pii/S0027510704000223

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