カテゴリー「thyroid cancer」
Title: Thyroid cancer in children and young adults in the North of England. Is increasing incidence related to the Chernobyl accident?
Author: Cotterill, S.J. / Pearce, M.S. / Parker, L.
Reference: European Journal of Cancer, 37 (8), p.1020-1026, May 2001
doi: 10.1016/S0959-8049(00)00449-4
Keywords: Thyroid neoplasms; Childhood cancer; Young adults; Iodine radioisotopes; Nuclear accidents
Abstract: Population-based data on thyroid carcinomas was obtained from the Northern Region Young Person’s Malignant Disease Registry to analyse the incidence of thyroid cancers in young people (<25 years) in the North of England for the period 1968 and 1997 and to assess if changes in incidence were consistent with the spatial and temporal distribution of the fallout from the Chernobyl nuclear accident. We compared incidence rates for differentiated (papillary or follicular) thyroid carcinomas 1968–1986 with those for 1987–1997. …These temporal and spatial changes in incidence are consistent with a causal association with the Chernobyl accident although a greater effect in the younger rather than the older age group would have been anticipated. However, factors including improvements in ascertainment and earlier detection of tumours may also have contributed to the increasing incidence. …
URL: http://www.sciencedirect.com/science/article/pii/S0959804900004494
Title: Thyroid cancer following Chernobyl
Author: Stiller, C.A.
Reference: European Journal of Cancer, 37 (8), p.945-947, May 2001
doi: 10.1016/S0959-8049(01)00072-7
Keywords:
Abstract: …radiation exposure from Chernobyl. Young people with thyroid cancer in the regions of…incidence rates for thyroid cancer post-Chernobyl among young people…Any increase in thyroid cancer risk related to Chernobyl would be expected to be…
URL: http://www.sciencedirect.com/science/article/pii/S0959804901000727
Title: The Chernobyl Tissue Bank, an international collaboration to investigate the relationship between the exposure to radiation in childhood and thyroid cancer
Author: Thomas, Geraldine A. / Tuttle, Michael / on behalf of the Collaborative Management Committee, Scientific Project Panel and Pathology and Blood Panels of the CTB,
Reference: International Congress Series, 1299, p.167-173, Feb 2007
doi: 10.1016/j.ics.2006.10.015
Keywords: Chernobyl; Tissue bank; Molecular biology
Abstract: The only unequivocal radiological effect of the Chernobyl accident on human health is the increase in thyroid cancer in those exposed in childhood. In response to the scientific interest in studying the molecular biology of thyroid cancer post-Chernobyl, the Chernobyl Tissue Bank (CTB: www.chernobyltissuebank.com) was established. The project is supported by the governments of Ukraine and Russia, and financially supported (US$3 M) by the European Commission, the National Cancer Institute of the USA, the Sasakawa Memorial Health Foundation of Japan and the World Health Organization. Full informed consent is obtained from donors; each case is subject to pathological review by an international panel. Aliquots of extracted nucleic acid (RNA and DNA from tissue, DNA from blood) serum are made available to researchers worldwide. …
URL: http://www.sciencedirect.com/science/article/pii/S0531513106005930
Title: Thyroid cancer in children and young adults in the North of England. Is increasing incidence related to the Chernobyl accident?
Author: Cotterill, S.J. / Pearce, M.S. / Parker, L.
Reference: European Journal of Cancer, 37 (8), p.1020-1026, May 2001
doi: 10.1016/S0959-8049(00)00449-4
Keywords: Thyroid neoplasms; Childhood cancer; Young adults; Iodine radioisotopes; Nuclear
Abstract: Population-based data on thyroid carcinomas was obtained from the Northern Region Young Person’s Malignant Disease Registry to analyse the incidence of thyroid cancers in young people (<25 years) in the North of England for the period 1968 and 1997 and to assess if changes in incidence were consistent with the spatial and temporal distribution of the fallout from the Chernobyl nuclear accident. We compared incidence rates for differentiated (papillary or follicular) thyroid carcinomas 1968–1986 with those for 1987–1997. …
URL: http://www.sciencedirect.com/science/article/pii/S0959804900004494
Title:Results of radioactive iodine treatment in children from Belarus with advanced stages of thyroid cancer after the Chernobyl accident,
Author: Reiners, Christoph / Biko, Johannes / Demidchik, Evgueni P / Demidchik, Yuri E / Drozd, Valentina M
Reference: International Congress Series, 1234, p.205-214, May 2002
doi: 10.1016/S0531-5131(01)00610-0
Keywords: Childhood thyroid cancer; Chernobyl; Radioiodine treatment
Abstract: Exposure of the thyroid to ionising radiation leads to an increased cancer risk. Whereas the average excess relative risk after external exposure amounts to approximately 8 per Gy, this relative risk is lower by a factor of 2 after exposure to radioiodine. The risk is greatest in newborns and small children below age of 5, intermediate in adolescents and questionable in adults. Papillary thyroid cancer with a relative incidence of approximately 80% per se is typical for thyroid cancer in childhood and adolescence; however, after exposure to radioiodine, this relative frequency is increased close to 100%. Bilateral involvement, multicentric growth and cancer not limited to the thyroid gland seem to be characteristic for radiation-induced thyroid cancer. Up to now, approximately 1500 cases of thyroid cancer in children below age of 15 have been diagnosed between 1990 and 2000 after the Chernobyl accident in Belarus, the Ukraine and Russia….
URL: http://www.sciencedirect.com/science/article/pii/S0531513101006100
Title: Dynamics of thyroid cancer incidence in Russia following the Chernobyl accident
Author: V K Ivanov / A I Gorsky / A F Tsyb / M A Maksyutov / E M Rastopchin
Reference: Journal of Radiological Protection, 19 (4), p.305-318, Dec 1999
doi: 10.1088/0952-4746/19/4/302
Keywords:
Abstract: This paper presents an analysis of thyroid cancer incidence in the territories of Russia most contaminated after the Chernobyl accident. In the work, data on incidence in the Bryansk, Kaluga, Orel and Tula regions (5298 000 persons) are used. Altogether, 2599 cases of thyroid cancer are considered from 1982 to 1995. Of them, 143 cases were among the population who were children and adolescents at the time of the accident in 1986. The work uses the approach based on comparison of distributions of thyroid cancer cases by age at diagnosis and age at exposure. It has been shown that since 1991 the age structure of the incidence has changed significantly with a growing proportion of cases among children and adolescents. …
URL: http://iopscience.iop.org/0952-4746/19/4/302/
Title: Time trends of thyroid cancer incidence in Ukraine after the Chernobyl accident
Author: W F Heidenreich / T I Bogdanova / A G Biryukov / N D Tronko
Reference: Journal of Radiological Protection, 24 (3), p.283-293, Sep 2004
doi: 10.1088/0952-4746/24/3/007
Keywords:
Abstract: The rate of childhood thyroid cancer incidence observed in northern Ukraine during the period 1986–1998 is described as a function of time-since-exposure, age-at-exposure, and sex. Conclusions are drawn for the excess absolute risk per dose: after a minimal latency period of about three years it shows a linear increase with time-since-exposure for at least nine years. It is roughly constant in age-at-exposure, up to 15 years. For girls exposed very young it is about a factor 2 larger than for boys. For children exposed at age 16–18 this ratio increases to about 5. The thyroids of young children are not more sensitive to radiation dose than those of older ones in absolute risk in northern Ukraine in the currently used data set. As the background is increasing with age, a constant absolute risk gives a decreasing relative risk.
URL: http://iopscience.iop.org/0952-4746/24/3/007/
Title: THYROID CANCER AND RADON LINK? A PREVIEW OF A HOSPITAL STUDY IN COLORADO SPRINGS, CO
Author: James F. Burkhart, Perri L. Dumbacher
Reference: AARST[PDF-386K] Sep 2008
Abstract: A case-control study looking at a possible correlation between indoor radon exposure and thyroid cancer is just beginning in the Colorado Springs area. The study was prompted by an observation by one of the principal investigators of the high incidence of thyroid nodules and cancers in her practice compared to the previous location at which she worked in Florida. A study has been designed which selects the cases (people with thyroid cancer) and the controls (those without thyroid cancer) from a local endocrinologist with a very large practice (hence the name, hospital study). …
URL: http://www.aarst.org/proceedings/2007/4-BurkhartRadon_and_thyroid_talk.pdf
Title: The Chernobyl Tissue Bank—integrating international research on thyroid cancer
Author: Thomas, Geraldine A.
Reference: International Congress Series, 1258, p.21-30, Nov 2003
doi: 10.1016/S0531-5131(03)01141-5
Keywords: Chernobyl; Thyroid cancer; Tissue bank; Radiation
Abstract: The Chernobyl Tissue Bank (CTB) is a research resource for both ongoing and future studies of the health consequences of the Chernobyl accident. To date, the only cancer to have shown a verified increase is thyroid cancer. The research so far suggests that it is primarily those who were youngest at the time of the accident who show the greatest risk, and the increase is largely restricted to one particular type of cancer of the thyroid follicular cell, papillary carcinoma. …
URL: http://www.sciencedirect.com/science/article/pii/S0531513103011415
Title: Chernobyl, radiation and thyroid cancer
Author: Williams, Dillwyn
Reference: International Congress Series, 1299, p.219-224, Feb 2007
doi: 10.1016/j.ics.2006.10.020
Keywords: Chernobyl; Radiation; Thyroid cancer; Latency; Mutation; Sensitivity
Abstract: The effects of radiation on man have been largely based on atomic bomb studies, Chernobyl exposure differs in radiation type, dose rate and tissue distribution. This review analyses the way in which Chernobyl studies have altered our understanding of radiation and thyroid carcinoma. Latency for radiation-related thyroid carcinoma is not fixed at 10 years; the time of detection of the first cases depends on the size of the outbreak. Radioiodine is not of low carcinogenicity, it is an effective thyroid carcinogen for young children for explicable reasons. Clinical, morphological and molecular studies after Chernobyl show a correlation with tumour latency, with short latency tumours largely showing RET PTC3 rearrangements, a solid type of papillary carcinoma and an aggressive clinical behaviour. …
URL: http://www.sciencedirect.com/science/article/pii/S0531513106006224
