Clinical Presentation and Clinical Outcomes in Chernobyl-related Paediatric Thyroid Cancers: What Do We Know Now? What Can We Expect in the Future?
Author: Tuttle, R.M. / Vaisman, F. / Tronko, M.D.
Reference: Clinical Oncology, 23 (4), p.268-275, May 2011
doi: 10.1016/j.clon.2011.01.178
Keywords: Chernobyl; outcomes; radiation; thyroid cancer
Abstract: Over the last 20 years, nearly 5000 cases of differentiated thyroid cancer have been diagnosed and treated in the regions of Russia, Ukraine and Belarus in young people previously exposed to the Chernobyl radioactive fallout during childhood. At diagnosis, 60–70% of the Chernobyl-related paediatric thyroid cancers had clinically evident cervical lymph node metastases (N1) and 10–15% had distant metastases (M1). Despite early reports suggesting that the paediatric thyroid cancer cases that developed after exposure to Chernobyl fallout were particularly aggressive, it now seems that the initial presentation and early clinical course of most of these cases are very similar to both non-radiation-associated paediatric thyroid cancers and thyroid cancers that arise after exposure to external beam irradiation….
URL:http://www.sciencedirect.com/science/article/pii/S0936655511002020
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