Cytogenetic study in lymphocytes from children exposed to ionizing radiation after the Chernobyl accident

Title: Cytogenetic study in lymphocytes from children exposed to ionizing radiation after the Chernobyl accident

Author: L. Padovani, D. Caporossi, B. Tedeschi, P. Vernole, B. Nicoletti, F. Mauro

Reference: Mutation Research/Genetic Toxicology, Volume 319, Issue 1, September 1993, Pages 55–60

DOI: http://dx.doi.org/10.1016/0165-1218(93)90030-H

Keywords: Chernobyl; Chromosome aberrations; Biological dosimetry

Abstract: The present study concerns the monitoring of children from the Byelorussian, Ukrainian and Russian republics exposed to the fall-out of the Chernobyl accident. Cytogenetic analyses have been performed on 41 children coming from different areas and exhibiting varying amounts of ¹³⁷Cs internal contamination, as evaluated by whole-body counter (WBC) analysis. On a total of 28670 metaphases scored, radiation-induced chromosome damage is still present, although at a very low frequency. Due to the very low fraction of dicentrics, because of the time elapsed from the accident and the relatively low doses of exposure, radiobiological dosimetry is not possible for these children. However, considering that the WBC data indicate that the children are still exposed to ¹³⁷Cs contamination, the observed occurrence of stable chromosome rearrangements and breaks may represent the persisting effect of continuous low doses of radiation. The present study also indicates that the parallel use of internal contamination dosimetry and cytogenetics could be usefully employed to monitor individual exposure to radiation and to define further management measures.

ＵＲＬ：http://www.sciencedirect.com/science/article/pii/016512189390030H

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