Mechanisms and pathogenesis of thyroid cancer in animals and man
Title: Mechanisms and pathogenesis of thyroid cancer in animals and man
Author: Williams, E.D.
Reference: Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 333 (1-2), p.123-129, Dec 1995
doi: 10.1016/0027-5107(95)00138-7
Keywords: Thyroid cancer; mechanisms and pathogenesis
Abstract: The transformation of the normal fully differentiated thyroid follicular cell to the rapidly growing undifferentiated anaplastic thyroid carcinoma cell involves a number of stages which have been defined morphologically and are now being related to various growth pathways and to molecular biological defects. The two main factors involved in this transformation are growth stimulation and mutagenesis…. The recent large increase in papillary carcinoma of the thyroid in children exposed to fallout from the Chernobyl nuclear accident underlines the importance of understanding the pathobiology of thyroid neoplasia.
URL: http://www.sciencedirect.com/science/article/pii/0027510795001387
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