Author: Shilyaeva, Tatyana Petrovna.
Reference: dissert. Cand. Med. Sci, Obninsk, 2003.
Keywords: liquidators, mortality
Author: Sitnikov, Sergey Grigorevich
Reference: dissert. Cand. Med. Sci. St. Petersburg. 2002
Keywords: liquidators, incidence
Author: KULIKOVA, Tat’yana Anatol’evna
Reference: Dissert. Cand. Med. Sci., Moscow, 206
Keywords: X-ray diagnosis, X-ray therapy
Abstract: Our aim is to identify features of the clinical course of chronic cerebrovascular insufficiency among liquidators of the Chernobyl accident and substantiating criteria for establishing causal relationship between the disease and participation in the emergency operations at the plant.
Author: Sokolova, Alexander Vladislavovna
Reference: Cand. Med Sci., Perm, 2000
Keywords: liquidators, polyneuropathy
Author: LAZAREVA, Sofia Antonovna
Reference: Dissert. Cand. Med. Sci., Perm, 2000
Keywords: liquidators, children
Author: CHEREDNIKOVA, Valentina Ivanovna
Reference : Dissert. Cand. Med. Sci, Moscow, 2000.
Title: Chromosomal aberrations and sister-chromatid exchanges in Lithuanian populations: effects of occupational and environmental exposures
Author: J.R Lazutka, R Lekevičius, V Dedonyt, L Maciulevičiūt Gervers, J Mierauskien, S Rudaitien, G Slapšyt
Reference: Mutation Research/Genetic Toxicology and Environmental Mutagenesis, Volume 445, Issue 2, 30 September 1999, Pages 225–239
DOI: http://dx.doi.org/10.1016/S1383-5718(99)00128-X
Keywords: Chromosomal aberration; Sister-chromatid exchange; Exposure; Heavy metal; Organic and inorganic volatile substance; Ionizing radiation; Chernobyl accident
Abstract: Cytogenetic analysis of chromosomal aberrations (CA) in 175,229 cells from 1113 individuals, both unexposed and occupationally or environmentally exposed to heavy metals (mercury and lead), organic (styrene, formaldehyde, phenol and benzo(a)pyrene) and inorganic (sulfur and nitrogen oxides, hydrogen and ammonium fluorides) volatile substances and/or ionizing radiation was performed. In addition, 11,250 cells from 225 individuals were scored for the frequency of sister-chromatid exchanges (SCE). Increased frequencies of CA were found in all occupationally exposed groups. A principal difference between the exposure to heavy metals and organic substances was found: increase in the CA frequency was dependent on duration of exposure to mercury but not dependent on duration of exposure to styrene, formaldehyde and phenol. A higher CA incidence was found in lymphocytes of children living in the vicinity of a plant manufacturing phosphate fertilizers. This indicates that children are a sensitive study group for the assessment of environmental exposure. However, the results of SCE analysis in these children were inconclusive. Exposure to ionizing radiation was found to cause chromosome breaks and chromatid exchanges in Chernobyl clean-up workers and chromatid breaks, chromatid exchanges, dicentric chromosomes and chromosome translocations in workers from the Ignalina Nuclear Power Plant. The increased frequency of chromatid exchanges in individuals exposed to ionizing radiation was quite unexpected. This may be attributed to the action of some unrecognized life-style or occupational factors, or to be a result of radiation-induced genomic instability. Also an increased SCE frequency was found in lymphocytes of Chernobyl clean-up workers.
ＵＲＬ：http://www.sciencedirect.com/science/article/pii/S138357189900128X
Title: Molecular Genetic Characterization of the Philadelphia Chromosome Detected in Reactor Personnel Highly Exposed to Radiation from the Chernobyl Accident
Author: Horst Zitzelsberger, Harald Hessel, Konstadinos Salassidis, Hans Mittermüller, Manfred Bauchinger
Reference: Cancer Genetics and Cytogenetics, Volume 104, Issue 2, 15 July 1998, Pages 86–93
DOI:http://dx.doi.org/10.1016/S0165-4608(97)00454-8
Keywords: chromosomes, liquidators
Abstract: Clonal del(22q) chromosome aberrations were coincidentally observed in highly exposed reactor personnel of the Chernobyl power plant accident in the course of retrospective biological dosimetry. These aberrant chromosomes were detected in PHA-stimulated cultures from peripheral blood after FPG staining and revealed a morphology similar to a Philadelphia chromosome. A rearrangement of the BCR gene on 22q11 could be confirmed in unstimulated peripheral blood by RFLP analysis from three of four del(22q) carrying cases. FISH analysis of the del(22q) carrying cases with BCR- and ABL-specific DNA probes additionally exhibited a BCR-ABL fusion in 5.2 to 9% of cells in unstimulated blood. Breakpoints within the BCR gene could be located either in the M-bcr or the m-bcr region and thus, a specific breakpoint region could not be detected in these four patients. Since typical clinical leukemic symptoms associated with the translocation (9;22)(q24;q11) could not be observed in these highly irradiated subjects (1.1 to 5.8 Gy), the role of this particular aberration in the development of a radiation-induced leukemia remains obscure.
ＵＲＬ：http://www.sciencedirect.com/science/article/pii/S0165460897004548
Title: Trends in the human sex odds at birth in Europe and the Chernobyl Nuclear Power Plant accident
Author: Hagen Scherb, Kristina Voigt
Reference: Reproductive Toxicology, Volume 23, Issue 4, June 2007, Pages 593–599
DOI: http://dx.doi.org/10.1016/j.reprotox.2007.03.008
Keywords: Analytical ecological study; Exposure–response relation; Low-level ionizing radiation; Male proportion; Radiation epidemiology; Radiation-induced genetic effects; Sex ratio; Spatial–temporal logistic regression
Abstract: To investigate trends in the sex odds before and after the Chernobyl accident, gender-specific annual birth statistics were obtained from the Czech Republic, Denmark, Finland, Germany, Hungary, Norway, Poland, and Sweden between 1982 and 1992. For parts of Germany, annual birth statistics and fallout measurements after Chernobyl are available at the district level. Trend models allowing for discontinuities of the male birth proportions are suggested. Superimposed on a downward trend in male proportions there was a jump in 1987 with a sex odds ratio of 1.0047 (95%-confidence interval: 1.0013–1.0081, p = 0.0061). A positive association of the male proportion in Germany between 1986 and 1991 with radioactive exposure at the district level is reflected by a sex odds ratio of 1.0145 per mSv/a (1.0021–1.0271, p = 0.0218). These findings suggest a possible long-term chronic influence of the Chernobyl Nuclear Power Plant accident on the human sex odds at birth in several European countries.
ＵＲＬ：http://www.sciencedirect.com/science/article/pii/S0890623807000445
Title: Increased level of chromosomal aberrations in lymphocytes of Chernobyl liquidators 6–10 years after the accident
Author: Natalia Slozina, Elizaveta Neronova, Tatiana Kharchenko, Alexey Nikiforov
Reference: Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, Volume 379, Issue 2, 6 October 1997, Pages 121–125
DOI:http://dx.doi.org/10.1016/S0027-5107(97)00113-9
Keywords: Chromosome aberration; Liquidator; Radiation; Micronucleus
Abstract: Chromosomal aberrations (CA) were used to investigate the level of cytogenetical damage in peripheral blood lymphocytes from the liquidators in a remote period (6–10 years) after the Chernobyl accident. There was a significantly higher frequency of chromosomal radiation markers (dicentrics and rings) in the peripheral lymphocytes of the liquidators than in the control subjects. No differences between these groups were demonstrated by the micronucleus (MN) test. Increased frequency of chromatid exchanges was associated with the smoking habits of the liquidators.
ＵＲＬ：http://www.sciencedirect.com/science/article/pii/S0027510797001139