Determination of the frequency of mutant cells on loci of glycophorin A and T- of cell receptor: to form (determine) group of risk in relationship with development of thyroid cancer

Author: A.O.Vereshagina

Reference: Dissertation, candidate of biology, Obninsk, 2006

Keywords: reevaluation of the relationship between radiation exposure and thyroid cancer, GPA-and-TCR-test, formation of groups of risk

Abstract: … the aim of this work was to elucidate a few questions.

1. People living in the contaminated areas, suffering from thyroid cancer: Do patients actually have elevated frequency of cells with gene mutations?
2. Does utilization of GPA-and TCR-test promise the formation of groups of risk for the occurrence of thyroid cancer? Informative evaluation of these tests for dosimetry at different doses to the thyroid gland is also of our interests.

To achieve these objectives, we were supposed to solve the following problems: 1) A comparative study of the frequency of occurrence of mutant cells by TCR-and GPA-loci among 1. residents affected by the Chernobyl disaster areas 2. people unexposed yet being under examination; 2) To determine whether there is a relationship between the dose absorbed by the thyroid and the frequency of mutant cells by GPA-and TCR-loci, among affected residents, as a result of the accident at the Chernobyl nuclear power plant (taking example of residents in Orel region) 3) a comparative study of the frequency of mutant cells, among residents in the Orel region 1. with benign nodular pathology on thyroid gland and 2. without it; 4) a comparative study of the frequency of mutant cells on 2 specified loci in 1. thyroid cancer patients before treatment and 2. healthy individuals; 5) to evaluate the possibility of using these tests for the formation of groups of risk, for the occurrence of thyroid cancer; …

URL: http://www.dissercat.com/content/opredelenie-chastoty-mutantnykh-kletok-po-lokusam-glikoforina-i-t-kletochnogo-retseptora-s-t