Ionizing radiation accelerating aging and neurodegeneration
Author: D.A. Bazyka, S.V. Volovik, K.G. Manton et al.
Reference: International Journal of Psychophysiology. — 2004. — Vol. 54, № 1–2. — P. 118–119.
タグ「premature aging」
Does ionizing radiation accelerate aging phenomena
Author: V. Bebeshko, D. Bazyka, K. Loganovsky et al.
Reference: Contributed papers to The International Conference “Twenty years after Chornobyl accident future outlook”, April 24–26, Kyiv, Ukraine. — Kyiv: HOLTEH, 2006. — P. 13–19.
Keywords: aging, DNA, immune function, nervous system effects
Abstract: Radiation accelerated aging might be a model of senescence in humans. Natural (normal) aging is a complex temporal process. Radiation is a phenomenon, which, by influencing cell structure and function, changes that process at the molecular and genetic level. A relation of aging and Ionizing Radiation (IR) could be demonstrated by involvement of similar mechanisms, e.g. free radical reactions, DNA repair, changes of immune function, altered lipid metabolism, nervous system effects, etc.
Concepts of immanent and interactional ambivalence (electron donor-acceptor dichotomy) of free radicals in their reactivity, and of free-radical ambivalence in biochemical processes, can be used to analyze free-radical function in normal and pathologic conditions including aging after IR exposure. Prospective epidemiological studies of atomic bomb survivors revealed IR significantly increased mortality for causes other than cancer. Results do not support claims survivors exposed to low IR doses live longer than comparable unexposed individuals. Whether exposure to low dose IR is a risk factor for accelerated aging and neurodegeneration is still unanswered and the biological mechanisms involved unknown. We propose: 1) exposure to low dose IR is a risk factor for accelerated aging and neurodegeneration; 2) heterogeneous pathogenetic factors contribute to the acceleration. International efforts to organize studies to test these hypotheses are of significance for radiation medicine and gerontology.
Neurological, neuropsychological and neurophysiological manifestations of premature aging in participants of liquidation of the Chernobyl accident.
Title: Neurological, neuropsychological and neurophysiological manifestations of premature aging in participants of liquidation of the Chernobyl accident
Author: Kholodova, Nina Balaevna
Reference: Moscow, 2011
Keywords: gerontology, geriatrics, neurologic manifestations, neuropsychological manifestations, neurophysiological manifestations, premature aging, liquidators
Abstract: The aim of this study was the development of the concept of premature aging of organism in liquidators working in the area of Chernobyl accident in 1986-87, during long-term after the works of liquidation of the accident’ consequences.