Cinétique intracolloïdale de l’iode dans la thyroïde de rat nouveau-né. Imagerie directe par microscopie ionique analytique
Author: Elbast, Mouhamad / Wu, Ting-Di / Guiraud-Vitaux, Françoise / Petiet, Anne / Hindié, Elif / Champion, Christophe / Croisy, Alain / (…) / Colas-Linhart, Nicole
Reference: Comptes Rendus Biologies, 331 (1), p.13-22, Jan 2008
doi: 10.1016/j.crvi.2007.10.005
Keywords: Thyroid follicle;Thyrocyte; Iodine; Kinetic; NanoSIMS50
Abstract: …The objective of this study is to describe the kinetic cellular distribution of newly organified iodine in the thyroid of newborn rats using secondary ion mass microscopy (NanoSIMS50). Ionic images obtained at high mass resolution and with a lateral resolution of about 50 nm show that the early distribution of iodine is heterogeneous from one follicle to another, from one thyrocyte to another inside the same follicle, and that this distribution varies as a function of time. The obtained kinetic profile will allow us to refine the studies concerning the aetiopathology of thyroid cancers of the Chernobyl children.
URL: http://www.sciencedirect.com/science/article/pii/S1631069107003356