Micronucleus formation in lymphocytes of children from the vicinity of Chernobyl after 131I therapy

Title: Micronucleus formation in lymphocytes of children from the vicinity of Chernobyl after ¹³¹I therapy

Author: W.-U. Müller, S. Dietl, K. Wuttke, C. Reiners, J. Biko, E. Demidchik, C. Streffer

Reference: Radiation and Environmental Biophysics , May 2004, Volume 43, Issue 1, pp 7-13

doi: 10.1007/s00411-004-0233-z

Keywords : Lymphocytes, children, Iodine-131, thyroid tumours

Abstract: After the Chernobyl accident a statistically significant increase in the number of children with thyroid tumours was observed. In this study 166 children with and 75 without thyroid tumours were analysed for micronucleus formation in peripheral blood lymphocytes using the cytochalasin B approach. The following factors did not significantly affect micronucleus formation: gender, age at the time of the first ¹³¹I treatment, tumour stage, tumour type, or metastases; a statistically significant increase in the number of micronuclei, however, was observed for the residents of Gomel compared to other locations, such as Brest, Grodno, and Minsk. The children with tumours received ¹³¹I treatment after surgical resection of the tumours. This gave us the opportunity to systematically follow the effect of ¹³¹I on micronucleus formation. A marked increase was observed 5 days after the ¹³¹I treatment followed by a decrease within a 4–7 months interval up to the next application, but the pre-treatment levels were not achieved. Up to 10 therapy cycles were followed each including an analysis of micronucleus formation before and 5 days after ¹³¹I application. The response of the children was characterised by clear individual differences and the increase/decrease pattern of micronucleus frequencies induced by iodine-131 was correlated with a decrease/increase pattern in the number of lymphocytes.

ＵＲＬ: http://link.springer.com/article/10.1007/s00411-004-0233-z

Irradiation and second cancers. The thyroid as a case in point

Title: Irradiation and second cancers. The thyroid as a case in point
Author: Schlumberger, Martin / Cailleux, Anne-Françoise / Suarez, Horacio G / de Vathaire, Florent

Reference: Comptes Rendus de l’Académie des Sciences – Series III – Sciences de la Vie, 322 (2-3), p.205-213, Feb 1999

doi: 10.1016/S0764-4469(99)80045-6

Keywords: irradiation; thyroid tumours; Chernobyl; RET rearrangements

Abstract: …Radioiodine 131 (1311) used for medical purposes has almost no tumourigenic effect on the adult thyroid gland. The consequences of the Chernobyl accident have clearly shown that the risk of thyroid cancer after exposure to 1311 in childhood is important, and that such exposure should be prevented by potassium iodine prophylaxis. RET/PTC rearrangements are found in 60–80 % of papillary carcinomas and in 45 % of adenomas occurring after radiation exposure. They are found in 5–15 % of papillary carcinoma and in no follicular adenomas that occurred in the absence of radiation exposure.

URL:http://www.sciencedirect.com/science/article/pii/S0764446999800456