Gene Expression Profiles for Radiation-induced Thyroid Cancer

Title: Gene Expression Profiles for Radiation-induced Thyroid Cancer

Author: Maenhaut, C. / Detours, V. / Dom, G. / Handkiewicz-Junak, D. / Oczko-Wojciechowska, M. / Jarzab, B.

Reference: Clinical Oncology, 23 (4), p.282-288, May 2011

doi: 10.1016/j.clon.2011.01.509

Keywords: Cancer; Chernobyl;papillary;radiation; thyroid; transcriptome

Abstract: The question whether radiation-induced thyroid cancer differs by its molecular biology from sporadic disease still remains. Studies on tissue from patients who developed thyroid cancer after the Chernobyl accident have provided a unique opportunity to look for biological consequences of low-dose irradiation by comparing the gene expression profile of sporadic papillary thyroid cancer (PTC), whose aetiology is unknown, and PTC induced by internal radiation. So far, four transcriptomic studies comparing radiation-induced and sporadic thyroid cancer have been reported….

URL: http://www.sciencedirect.com/science/article/pii/S0936655511005413