Gene rearrangements in thyroid carcinomas after irradiation during childhood: lessons from the Chernobyl reactor accident

Title: Gene rearrangements in thyroid carcinomas after irradiation during childhood: lessons from the Chernobyl reactor accident

Author: Rabes, Hartmut M

Reference: International Congress Series, 1234, p.193-200, May 2002

doi: 10.1016/S0531-5131(01)00608-2

Keywords: Papillary thyroid carcinoma; Gene rearrangement; DNA breakpoints; Irradiation; RET

Abstract: Papillary thyroid carcinomas (PTC) developed with a high incidence in children and young adults who had been exposed to radioactive fallout in contaminated regions of Belarus after the Chernobyl reactor accident. They are informative for a molecular genetic analysis of radiation-induced PTC. In contrast to spontaneous PTC, a high prevalence of gene aberrations was found with rearrangements of the receptor tyrosine kinase gene RET in the majority of cases and a few NTRK1 rearrangements. In the rearranged form of RET, the transmembrane and extracellular parts are replaced by regulatory units of other genes….

URL: http://www.sciencedirect.com/science/article/pii/S0531513101006082

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