Molecular epidemiology of childhood thyroid cancer around Chernobyl

Title: Molecular epidemiology of childhood thyroid cancer around Chernobyl

Author: Yamashita, Shunichi / Shibata, Yoshisada / Namba, Hiroyuki / Takamura, Noboru / Saenko, Vladimir,

Reference: International Congress Series, 1236, p.201-205, Jul 2002

doi: 10.1016/S0531-5131(01)00855-X

Keywords: Chernobyl; Screening ; Thyroid cancer; Gene rearrangement; Signal transduction

Abstract: …The comparative study of thyroid diseases demonstrates the likelihood of short-lived radioactive iodine on thyroid cancer in the children born before the Chernobyl accident. Next, at the standpoint of recent molecular analysis of thyroid carcinogenesis, many reports now indicate evidence of a high incidence of ret/PTC gene rearrangement in childhood thyroid cancer tissues. Besides ret/PTC gene rearrangement, the disturbance of the response of intracellular signal transduction to radiation exposure is also important in thyroid cells, and results demonstrate that radiation exposure could cause abnormal thyroid cell proliferation specifically through constitutive activation of intracellular target molecules via membrane lipid breakdown, and subsequently disturb the apoptosis-prone pathway. …Therefore, the late effect of radiation, even in the lower dose on the human thyroid glands, should be monitored carefully for the radiation-sensitive vulnerable group for a longer period, especially around Chernobyl.

URL: http://www.sciencedirect.com/science/article/pii/S053151310100855X

キーワードタグ

前後へのリンク