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Study of lymphocyte activation reactions to neuro-specific antigenes in Сhernobyl clean-up workers against the doses of radiation exposure

Author: V.I. Khomenko

Reference: Український медичний часопис. (Ukirainian Medical magazine), 2008

Keywords: Chernobyl accident, autoimmune reactions, protein S-100, myelin basic protein

Abstract: In Chernobyl clean-up workers with cerebrovascular pathology who were irradiated with a range of doses from 30 to 94 cSv the reliable rise of HLA-DR+ lymphocytes activation under protein S-100 stimulation is revealed in comparison with those irradiated in doses up to 30 cSv. It probably testify to the alteration of the glial structures in the central nervous system (CNS) and blood-brain barrier (BBB), that increases under the higher doses irradiation. Glial and endothelial cells of brain vessels are elements of BBB. Conclusions about a probable increase of permeability of the BBB in Chernobyl clean-up workers with cerebrovascular pathology who were irradiated in a range of doses from 30 to 94 cSv, correspond to the results of other studies that have demonstrated an increase of the cerebrovascular discirculation with development of the white and grey brain matter atrophy with the threshold dose for occurrence of these changes 30 cSv. Delay of the HLA-DR+ lymphocyte activation that we observed below this threshold dose is probably connected with the influence of CD4-8+-Т cells on the lymphocyte activation.

URL: http://www.umj.com.ua/article/2215/stan-aktivacijnix-reakcij-limfocitiv-na-nejrospecifichni-antigeni-v-ulna-na-chaes-zalezhno-vid-doz-oprominennya

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