Comet assay on children’s leukocytes 8 years after the Chernobyl disaster

Title: Comet assay on children’s leukocytes 8 years after the Chernobyl disaster

Author: Frenzilli, G / Lori, A / Panasiuk, G / Ferdeghini, M / Barale, R

Reference: Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 415 (1-2), p.151-158, Jul 1998

doi: 10.1016/S1383-5718(98)00060-6

Keywords: Single cell gel electrophoresis; Human leukocyte; DNA damage; Bleomycin; Adaptive response

Abstract…. The children come from the Gomel region, one of the areas most heavily radio-contaminated by the Chernobyl fallout. In addition, leukocytes were treated with a challenge dose of bleomycin (BLM, 1.5 μg/ml), to assess the presence of an adaptive response (AR) potentially resulting from chronic exposure to radionuclides. As controls, 13 children living in Pisa (Italy) were enrolled in the study. Children with thyroid cancer show higher (p<0.001) DNA damage than healthy ones.. …

URL: http://www.sciencedirect.com/science/article/pii/S1383571898000606