タグ「thyroid cancer (child)」
Title: Clinical Presentation and Clinical Outcomes in Chernobyl-related Paediatric Thyroid Cancers: What Do We Know Now? What Can We Expect in the Future?
Author: Tuttle, R.M. / Vaisman, F. / Tronko, M.D.
Reference: Clinical Oncology, 23 (4), p.268-275, May 2011
doi: 10.1016/j.clon.2011.01.178
Keywords: Chernobyl; outcomes; radiation; thyroid cancer
Abstract: Over the last 20 years, nearly 5000 cases of differentiated thyroid cancer have been diagnosed and treated in the regions of Russia, Ukraine and Belarus in young people previously exposed to the Chernobyl radioactive fallout during childhood. At diagnosis, 60–70% of the Chernobyl-related paediatric thyroid cancers had clinically evident cervical lymph node metastases (N1) and 10–15% had distant metastases (M1). Despite early reports suggesting that the paediatric thyroid cancer cases that developed after exposure to Chernobyl fallout were particularly aggressive, it now seems that the initial presentation and early clinical course of most of these cases are very similar to both non-radiation-associated paediatric thyroid cancers and thyroid cancers that arise after exposure to external beam irradiation….
URL:http://www.sciencedirect.com/science/article/pii/S0936655511002020
Title: Thyroid cancer 15 years after Chernobyl
Author: Shibata, Yoshisada
Reference: The Lancet, 359 (9321), p.1947, Jun 2002
doi: 10.1016/S0140-6736(02)08753-6
Keywords:
Abstract: …increase in childhood thyroid cancer reported since the Chernobyl accident was not due…district who underwent thyroid assessments in the Chernobyl
Sasakawa Health and Medical…time of examination and thyroid cancer was detected in ten boys…
URL: http://www.sciencedirect.com/science/article/pii/S0140673602087536
Title: 530 Clinical aspects and surgical treatment of post-chernobyl children’s and adolescents thyroid cancer
Author: Komissarenko, I.V. / Rybakov, S.I. / Kovalenko, A.Y. / Kvachenyuk, A.N.
Reference: European Journal of Cancer, 31 (Supplement 6), p.S113, Nov 1995
doi: 10.1016/0959-8049(95)95784-4
Keywords:
Abstract: The cases of children’s and adolescent’s thyroid cancer treated in the Surgical Clinic of the Institute of Endocrinology and Metabolism during the period from 1980 to 1994 were reviewed retrospectively. 199 patients with thyroid cancer were operated on. The analysis has shown a substantial increase in thyroid cancer incidence among children in Ukraine after the Chernobyl accident (1990 to 1994) which differs by its clinical characteristics and a high level of aggression….
URL:http://www.sciencedirect.com/science/article/pii/0959804995957844
Title: Summary of the 15-year observation of thyroid cancer among Ukrainian children after the Chernobyl accident
Author: Tronko, Nikolay D / Bogdanova, Tatiana I / Likhtarev, Ilya A / Kairo, Irina A / Shpak, Viktor I
Reference: International Congress Series, 1234, p.77-83, May 2002
doi: 10.1016/S0531-5131(01)00597-0
Keywords: Thyroid cancer; Children; Register; Exposure doses; Pathology
Abstract: According to the data of the clinico-morphological register of the Institute of Endocrinology and Metabolism in Ukraine, for the post-Chernobyl period in Ukraine (1986–2000), 472 cases of thyroid cancer have been reported in children who have been operated at the age of up to 15 years, among which, 431 were born before the Chernobyl accident, 11 were “in utero” at the time of the accident, and 30 were born after the Chernobyl accident. The largest number of cases (57) has been reported in 1996, which made up 0.57 per 100 000 children aged 0–14, and exceeded by 11.4 times the average pre-Chernobyl incidence rate (0.05) in this age group. The highest incidence rate has been reported in six regions of Ukraine which have been the most contaminated by iodine radionuclides (Kiev, Chernigov, Zhitomir, Rovno, Cherkassy regions, and Kiev City). …
URL: http://www.sciencedirect.com/science/article/pii/S0531513101005970
Title: Thyroid cancer in children and young adults in the North of England. Is increasing incidence related to the Chernobyl accident?
Author: Cotterill, S.J. / Pearce, M.S. / Parker, L.
Reference: European Journal of Cancer, 37 (8), p.1020-1026, May 2001
doi: 10.1016/S0959-8049(00)00449-4
Keywords: Thyroid neoplasms; Childhood cancer; Young adults; Iodine radioisotopes; Nuclear accidents
Abstract: Population-based data on thyroid carcinomas was obtained from the Northern Region Young Person’s Malignant Disease Registry to analyse the incidence of thyroid cancers in young people (<25 years) in the North of England for the period 1968 and 1997 and to assess if changes in incidence were consistent with the spatial and temporal distribution of the fallout from the Chernobyl nuclear accident. We compared incidence rates for differentiated (papillary or follicular) thyroid carcinomas 1968–1986 with those for 1987–1997. …These temporal and spatial changes in incidence are consistent with a causal association with the Chernobyl accident although a greater effect in the younger rather than the older age group would have been anticipated. However, factors including improvements in ascertainment and earlier detection of tumours may also have contributed to the increasing incidence. …
URL: http://www.sciencedirect.com/science/article/pii/S0959804900004494
Title: Thyroid cancer in children and young adults in the North of England. Is increasing incidence related to the Chernobyl accident?
Author: Cotterill, S.J. / Pearce, M.S. / Parker, L.
Reference: European Journal of Cancer, 37 (8), p.1020-1026, May 2001
doi: 10.1016/S0959-8049(00)00449-4
Keywords: Thyroid neoplasms; Childhood cancer; Young adults; Iodine radioisotopes; Nuclear
Abstract: Population-based data on thyroid carcinomas was obtained from the Northern Region Young Person’s Malignant Disease Registry to analyse the incidence of thyroid cancers in young people (<25 years) in the North of England for the period 1968 and 1997 and to assess if changes in incidence were consistent with the spatial and temporal distribution of the fallout from the Chernobyl nuclear accident. We compared incidence rates for differentiated (papillary or follicular) thyroid carcinomas 1968–1986 with those for 1987–1997. …
URL: http://www.sciencedirect.com/science/article/pii/S0959804900004494
Title:Results of radioactive iodine treatment in children from Belarus with advanced stages of thyroid cancer after the Chernobyl accident,
Author: Reiners, Christoph / Biko, Johannes / Demidchik, Evgueni P / Demidchik, Yuri E / Drozd, Valentina M
Reference: International Congress Series, 1234, p.205-214, May 2002
doi: 10.1016/S0531-5131(01)00610-0
Keywords: Childhood thyroid cancer; Chernobyl; Radioiodine treatment
Abstract: Exposure of the thyroid to ionising radiation leads to an increased cancer risk. Whereas the average excess relative risk after external exposure amounts to approximately 8 per Gy, this relative risk is lower by a factor of 2 after exposure to radioiodine. The risk is greatest in newborns and small children below age of 5, intermediate in adolescents and questionable in adults. Papillary thyroid cancer with a relative incidence of approximately 80% per se is typical for thyroid cancer in childhood and adolescence; however, after exposure to radioiodine, this relative frequency is increased close to 100%. Bilateral involvement, multicentric growth and cancer not limited to the thyroid gland seem to be characteristic for radiation-induced thyroid cancer. Up to now, approximately 1500 cases of thyroid cancer in children below age of 15 have been diagnosed between 1990 and 2000 after the Chernobyl accident in Belarus, the Ukraine and Russia….
URL: http://www.sciencedirect.com/science/article/pii/S0531513101006100
Title: Time trends of thyroid cancer incidence in Ukraine after the Chernobyl accident
Author: W F Heidenreich / T I Bogdanova / A G Biryukov / N D Tronko
Reference: Journal of Radiological Protection, 24 (3), p.283-293, Sep 2004
doi: 10.1088/0952-4746/24/3/007
Keywords:
Abstract: The rate of childhood thyroid cancer incidence observed in northern Ukraine during the period 1986–1998 is described as a function of time-since-exposure, age-at-exposure, and sex. Conclusions are drawn for the excess absolute risk per dose: after a minimal latency period of about three years it shows a linear increase with time-since-exposure for at least nine years. It is roughly constant in age-at-exposure, up to 15 years. For girls exposed very young it is about a factor 2 larger than for boys. For children exposed at age 16–18 this ratio increases to about 5. The thyroids of young children are not more sensitive to radiation dose than those of older ones in absolute risk in northern Ukraine in the currently used data set. As the background is increasing with age, a constant absolute risk gives a decreasing relative risk.
URL: http://iopscience.iop.org/0952-4746/24/3/007/
Title: BAC-FISH assays delineate complex chromosomal rearrangements in a case of post-Chernobyl childhood thyroid cancer
Author: Kwan, Johnson / Baumgartner, Adolf / Lu, Chun-Mei / Wang, Mei / Weier, Jingly F. / Zitzelsberger, Horst F. / Weier, Heinz-Ulrich G.,
Reference:Mar 2009
doi: 10.2172/983040
Abstract: …case of post-Chernobyl childhood thyroid cancer * Johnson Kwan……prepared from a thyroid cancer that arose following…nuclear accident in Chernobyl, Ukraine [30
Key words : thyroid cancer, radiation, Chernobyl, chromosome aberration…
URL:http://www.osti.gov/bridge/product.biblio.jsp?query_id=2&page=0&osti_id=983040
Author: Igumnov, S.A. / Drozdovitch, V.V.
Reference: European Psychiatry, 13 (Supplement 4), p.313s, Jan 1998
doi: 10.1016/S0924-9338(99)80644-0
Abstract: …DEVELOPMENT OF CHILDREN WITH THYROID CANCER EXPOSED FOLLOWING THE CHERNOBYL ACCIDENT (CLINICAL AND DOSIMETRY…children at the age 10-15 with thyroid cancer exposed following the Chemobyl…investigation the individual thyroid doses from 131 1have been…
URL: : Descriptive epidemiology of thyroid cancer in France: Incidence, mortality and survival,
