Chromosomal Aberrations in Blood Lymphocytes of the Residents of 30-km Chornobyl NPP Exclusion Zone

Title: Chromosomal Aberrations in Blood Lymphocytes of the Residents of 30-km Chornobyl NPP Exclusion Zone

Author: Larysa BEZDROBNA, Tetyana TSYGANOK, Olena ROMANOVA, Larysa TARASENKO, Volodymyr TRYSHYN and Ludmila KLIMKINA

Reference: Institute for Nuclear Research, National Academy of Science of Ukraine

Keywords: lymphocytes, Chernobyl exclusion zone, chromosomal aberrations, Ukraine

Abstract: A comparative сytogenetic examination of 33 self-settlers in the 30 km ChNPP Exclusion Zone and 31 residents in villages of Yahotyn district, Kyiv region was carried out in 1998-99.

ＵＲＬ：http://www.rri.kyoto-u.ac.jp/NSRG/reports/kr79/kr79pdf/Bezdrobna.pdf

Cytogenetic study on children living in Southern Urals contaminated areas (nuclear incidents 1948–1967)

Title: Cytogenetic study on children living in Southern Urals contaminated areas (nuclear incidents 1948–1967)

Author: A Testa, L Padovani, F Mauro, M Appolloni, P Anzidei, L Stronati

Reference: Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, Volume 401, Issues 1–2, 5 June 1998, Pages 193–197

DOI: http://dx.doi.org/10.1016/S0027-5107(98)00008-6

Keywords: Southern Urals; Radiation exposure; Cytogenetics; Chromosome aberration

Abstract: As a result of the activities of the first Soviet plutonium production reactor, large territories of the Southern Urals were exposed to radioactive contamination. Three different incidents occurring between 1948 and 1967 lead to major exposure. A total of 280,000 people residing on the contaminated territories were exposed both to external and internal contamination particularly due to the long-lived radionuclides ¹³⁷Cs and ⁹⁰Sr. The highest doses were received by 28,000 people living on the Techa riverside villages. In the present paper 15 presumably exposed children coming from the Muslyumovo village on the Techa river have been analyzed using conventional cytogenetic procedure in order to assess a radiation-induced damage. The data obtained have been compared to a group of matched unexposed controls. The results show a statistical difference between the two cohorts which suggests a possible residual contamination representing a continuous hazard for the new generations.

ＵＲＬ：http://www.sciencedirect.com/science/article/pii/S0027510798000086

An increased frequency of structural chromosome aberrations in persons present in the vicinity of Chernobyl during and after the reactor accident. Is this effect caused by radiation exposure?

Title: An increased frequency of structural chromosome aberrations in persons present in the vicinity of Chernobyl during and after the reactor accident. Is this effect caused by radiation exposure?

Author: G. Stephan, U. Oestreicher

Reference: Mutation Research/Genetic Toxicology, Volume 223, Issue 1, May 1989, Pages 7–12

DOI: http://dx.doi.org/10.1016/0165-1218(89)90057-8

Keywords: Chernobyl; Chromosome aberration; Human; Radiation effect

Abstract: About a week after the reactor accident in Chernobyl, a number of German citizens returned to the Federal Republic of Germany from different places of residence in the U.S.S.R. Chromosome analyses of these individuals show a surprisingly significant increase in dicentric chromosomes in comparison to the laboratory control. Acentrics are nearly twice as frequent as dicentrics. Centric rings are also in evidence. Chromatid breaks do not significantly differ from the control with the exception of 1 place of residence.

The frequency of aberrations is too high to be induced by absorbed doses calculated physically or by modelling techniques. So far, no explanation is available for the discrepancy – a factor of about 100 – between calculated absorbed doses and the measured biological effect.

ＵＲＬ：http://www.sciencedirect.com/science/article/pii/0165121889900578

Cytogenetic study in lymphocytes from children exposed to ionizing radiation after the Chernobyl accident

Title: Cytogenetic study in lymphocytes from children exposed to ionizing radiation after the Chernobyl accident

Author: L. Padovani, D. Caporossi, B. Tedeschi, P. Vernole, B. Nicoletti, F. Mauro

Reference: Mutation Research/Genetic Toxicology, Volume 319, Issue 1, September 1993, Pages 55–60

DOI: http://dx.doi.org/10.1016/0165-1218(93)90030-H

Keywords: Chernobyl; Chromosome aberrations; Biological dosimetry

Abstract: The present study concerns the monitoring of children from the Byelorussian, Ukrainian and Russian republics exposed to the fall-out of the Chernobyl accident. Cytogenetic analyses have been performed on 41 children coming from different areas and exhibiting varying amounts of ¹³⁷Cs internal contamination, as evaluated by whole-body counter (WBC) analysis. On a total of 28670 metaphases scored, radiation-induced chromosome damage is still present, although at a very low frequency. Due to the very low fraction of dicentrics, because of the time elapsed from the accident and the relatively low doses of exposure, radiobiological dosimetry is not possible for these children. However, considering that the WBC data indicate that the children are still exposed to ¹³⁷Cs contamination, the observed occurrence of stable chromosome rearrangements and breaks may represent the persisting effect of continuous low doses of radiation. The present study also indicates that the parallel use of internal contamination dosimetry and cytogenetics could be usefully employed to monitor individual exposure to radiation and to define further management measures.

ＵＲＬ：http://www.sciencedirect.com/science/article/pii/016512189390030H

Analysis of the results of cytogenetic studies of people living in radioactively contaminated areas after the Chernobyl accident

Title: Analysis of the results of cytogenetic studies of people living in radioactively contaminated areas after the Chernobyl accident

Author: Mikhailova, Galina　Fyodorovna

Reference: Obninsk, 2007

Keywords: radiobiology, cytogenetic studies, radioactive contamination, chromosomal aberrations, chronic low-intensity radiation, somatic cells

Abstract: The aim of this study is to examine the patterns of the effects of chronic low-intensity radiation on the genetic structure of the somatic cells of people living in areas with different density of radioactive contamination from the Chernobyl accident.

URL:http://www.dissercat.com/content/analiz-rezultatov-tsitogeneticheskikh-issledovanii-naseleniya-prozhivayushchego-na-radioakti

Chernobyl Studies Project: Working group 7.0, Environmental transport and health effects. Progress report, March–September 1994

Title: Chernobyl Studies Project: Working group 7.0, Environmental transport and health effects. Progress report, March–September 1994

Author: Anspaugh, L.R. / Hendrickson, S.M. [eds.]

Reference: DOE Scientific and Technical Informatio Dec 1994

doi: 10.2172/112330

Keywords: 56 BIOLOGY AND MEDICINE, APPLIED STUDIES ;22 NUCLEAR REACTOR TECHNOLOGY ;05 NUCLEAR FUELS; REACTOR ACCIDENTS; HEALTH HAZARDS; CHERNOBYLSK-3 REACTOR; THYROID; RADIATION DOSES; CHROMOSOMAL ABERRATIONS; LEUKEMIA; CHILDREN; PROGRESS REPORT

Abstract: …associated with the Chernobyl accident, and (3…broader in scope than just Chernobyl, and the agreement…a direct part of the Chernobyl Project. However…See Section 7.2F – Thyroid Studies for the resolution…childhood-thyroid cancer. III. Significant…

URL:http://www.osti.gov/bridge/product.biblio.jsp?query_id=2&page=0&osti_id=112330