タグ「fluorescence in situ hybridization」
Title: Delineating Chromosomal Breakpoints in Radiation-Induced Papillary Thyroid Cancer
Author: Heinz-Ulrich G. Weier, Yuko Ito, Johnson Kwan, Jan Smida , Jingly F. Weier, Ludwig Hieber, Chung-Mei Lu, Lars Lehmann, Mei Wang, Haig J. Kassabian, Hui Zeng, Benjamin O’Brien
Reference: Genes 2011, 2, 397-419; [PDF-768K]Jul 2011
doi: 10.3390/genes2030397
Keywords: Chernobyl; neoplastic disease; papillary thyroid cancer; translocation; molecular cytogenetics; breakpoint delineation; fluorescence in situ hybridization; bacterial artificial chromosomes
Abstract: …tumors and papillary thyroid carcinomas (PTCs…regions. Keywords: Chernobyl neoplastic disease papillary thyroid cancer translocation molecular…studies of post-Chernobyl cases of PTC…radiation-induced childhood thyroid cancer: S96T, as…
URL: http://www.mdpi.com/2073-4425/2/3/397/pdf-vor
Title: Molecular cytogenetic characterization of a human thyroid cancercell line
Author: Weier, Heinz-Ulrich G. / Tuton, Tiffany B. / Ito, Yuko / Chu, LisaW. / Lu, Chung-Mei / Baumgartner, Adolf / Zitzelsberger, Horst F. / Weier, Jingly F.
Reference: Cytogenetics and Genome Research; Journal Volume: 114; Related Information: Journal Publication Date: 2006
Keywords: Thyroid cancer, Chernobyl, radiation effects, cytogenetics, structural chromosome aberrations, fluorescence in situ hybridization, spectral karyotyping, chromosome
Abstract: The incidence of papillary thyroid carcinoma (PTC) increases significantly after exposure of the head and neck region to ionizing radiation, yet we know neither the steps involved in malignant transformation of thyroid epithelium nor the specific carcinogenic mode of action of radiation. Such increased tumor frequency became most evident in children after the 1986 nuclear accident in Chernobyl, Ukraine. …To study the etiology of radiation-induced thyroid cancer, we formed an international consortium to investigate chromosomal changes and altered gene expression in cases of post-Chernobyl chPTC. Our approach is based on karyotyping of primary cultures established from chPTC specimens, establishment of cell lines and studies of genotype-phenotype relationships through high resolution chromosome analysis, DNA/cDNA micro-array studies, and mouse xenografts that test for tumorigenicity….
URL: http://www.osti.gov/bridge/purl.cover.jsp?purl=/901816-6SPdNw/
Title: Delineating Chromosomal Breakpoints in Radiation-Induced Papillary Thyroid Cancer
Author: Heinz-Ulrich G. Weier, Yuko Ito, Johnson Kwan, Jan Smida, Jingly F. Weier, Ludwig Hieber, Chun-Mei Lu, Lars Lehmann , Mei Wang , Haig J. Kassabian, Hui Zeng, Benjamin O’Brien
Reference: [PDF-770K]Jul 2011
Keywords: Chernobyl; neoplastic disease; papillary thyroid cancer; translocation; molecular cytogenetics; breakpoint delineation; fluorescence in situ hybridization; bacterial artificial chromosomes
Abstract: …tumors and papillary thyroid carcinomas (PTCs…regions. Keywords: Chernobyl neoplastic disease papillary thyroid cancer translocation molecular…studies of post-Chernobyl cases of PTC…radiation-induced childhood thyroid cancer: S96T, as…
URL: http://www.mdpi.com/2073-4425/2/3/397/pdf
BAC-FISH assays delineate complex chromosomal rearrangements in a case of post-Chernobyl childhood thyroid cancer
Author: Kwan, Johnson / Baumgartner, Adolf / Lu, Chun-Mei / Wang, Mei / Weier, Jingly F. / Zitzelsberger, Horst F. / Weier, Heinz-Ulrich G.,
Reference: Mar 2009
doi: 10.2172/983040
Keywords: thyroid cancer, radiation, Chernobyl, chromosome aberration, translocation, fluorescence in situ hybridization (FISH), DNA probes, bacterial artificial chromosome.
Abstract: :…case of post-Chernobyl childhood thyroid cancer * Johnson Kwan…Key words : thyroid cancer, radiation, Chernobyl, chromosome aberration…prepared from a thyroid cancer that arose following…nuclear accident in Chernobyl, Ukraine [30…
URL: http://www.osti.gov/bridge
