Author: O.V. Sokolova
Reference: St. Petersburg 2009 Abstract HAC Russia 14.00.15
Keywords: follicular tumors, substantiate diagnostic criteria
Abstract: Aim of the study: To study and compare assessment of histological, morphometric and immunohistochemical features of follicular thyroid tumors, in different degrees of malignancy, to identify and to substantiate differential diagnostic criteria.
Title: Can different thyroid tumor types be distinguished by polymerase chain reaction-based K- ras mutation detection?
Author: Apple, Sophia K. / Alzona, Maria C. / Jahromi, Soraya A. / Grody, Wayne W.
Reference: Molecular Diagnosis, 3 (3), p.143-148, Sep 1998
doi: 10.1016/S1084-8592(98)80032-5
Keywords: follicular adenoma; follicular carcinoma; papillary carcinoma; oncogenes
Abstract: Thyroid tumors have mutations of the ras oncogenes, although the prognostic and diagnostic significance of this remains unclear. Usually, thyroid follicular adenoma, follicular carcinoma, and papillary carcinoma are easy to differentiate histologically. Occasionally, follicular carcinoma may be difficult to separate from the follicular variant of papillary carcinoma, and a molecular test to help differentiate the two would be critical, as their behavior and clinical management differ. In earlier reports, K-ras mutations have been suggested as such a marker.
…normal and proliferative thyroid tissues. Am J Pathol…carcinomas arising from thyroid epithe- lial follicular cells. Gene Chromosomes Cancer 1996;16:1-14 22…benign and malignant thyroid tumors from children…to radiation after the Chernobyl nuclear accident. Oncogene…
URL: http://www.sciencedirect.com/science/article/pii/S1084859298800325