Author: Nakane Y., Ohta Y.
Reference: Psychiatric case registers in public health. G.H.M.M. Ten Horn, R. Giel, W.H. Gulbinat, J.H. Henderson (Eds.). — Amsterdam: Elsevier Science Publishers B.V., 1986. — P. 26–27.
Author: Y. Imamura, Y. Nakane, Y. Ohta, H. Kondo
Reference: Acta Psychiatr. Scand. — 1999. — Vol. 100, № 5. — P. 344–349.
Keywords: schizophrenia, risk factor
Abstract: OBJECTIVE: The aim of this study was to examine the relationship between prenatal exposure to atomic bomb (A-bomb) radiation and the development of schizophrenia in adulthood.
METHOD: We investigated the lifetime prevalence of schizophrenia among people prenatally exposed to the 1945 Nagasaki A-bomb, using the schizophrenia register and the A-bomb survivors’ database.
RESULTS: Among 1867 prenatally exposed individuals, 18 subjects (0.96%) had developed schizophrenia later in life. The prevalence was significantly higher in people exposed in the second trimester of pregnancy than in those exposed in the third trimester. The closer they had been to the hypocentre, the higher was the prevalence, but no statistically significant linear relationship was seen.
CONCLUSION: This investigation could not clarify the nature of exposure to A-bomb radiation as a risk factor for schizophrenia in the prenatal period.
Title: In utero exposure to A-bomb radiation and mental retardation; a reassessment
Author: Masanori Otake, Ph.D. and William J. Schull, Ph.D.
Reference: British Journal of Radiology (1984) 57, 409-414
doi: 10.1259/0007-1285-57-677-409
Keywords: utero exposure, A-bomb, Hiroshima, Nagasaki, mental retardation
Abstract: The prevalence of mental retardation in children exposed in utero to the atomic bombs in Hiroshima and Nagasaki has been re-evaluated in reference to gestational age and tissue dose in the fetus. There was no risk at 0–8 weeks postconception. The highest risk of forebrain damage occurred at 8–15 weeks of gestational age, the time when the most rapid proliferation of neuronal elements and when most, if not all, neuroblast migration to the cerebral cortex from the proliferative zones is occurring. Overall, the risk is five or more times greater in these weeks than in subsequent ones. In the critical period, damage expressed as the frequency of subsequent mental retardation appears to be linearly related to the dose received by the fetus. A linear model is not equally applicable to radiation-related mental retardation after the 15th week, the observed values suggesting that there a threshold may exist. The data are consistent with a probability of occurrence of mental retardation of 0.40% per cGy or 40% per gray.
Author: K.Yu. Antipchuk
Reference: dissertation, 2005, Kiev
Keywords: cerebral system, Hiroshima Nagasaki, socio-medical aspect
Abstract: Currently, more and more clinical and experimental data reveal the effect of ionizing radiation onto the cerebral system. Epidemiological data of Hiroshima and Nagasaki also show the important role of ionizing radiation in the formation of non-tumor pathology and mortality… The work describes some socio-medical aspects of the aftermaths of the Chernobyl catstrophe. Shows dose-dependent markers of various pathologies. Introduces research results of researchers from all over the world.
(full article available on-line in Ukrainian)
URL: http://librar.org.ua/sections_load.php?s=medicine&id=2491