Molecular cytogenetic characterization of a human thyroid cancercell line

Title: Molecular cytogenetic characterization of a human thyroid cancercell line

Author: Weier, Heinz-Ulrich G. / Tuton, Tiffany B. / Ito, Yuko / Chu, LisaW. / Lu, Chung-Mei / Baumgartner, Adolf / Zitzelsberger, Horst F. / Weier, Jingly F.
Reference: Cytogenetics and Genome Research; Journal Volume: 114; Related Information: Journal Publication Date: 2006

Keywords: Thyroid cancer, Chernobyl, radiation effects, cytogenetics, structural chromosome aberrations, fluorescence in situ hybridization, spectral karyotyping, chromosome

Abstract: The incidence of papillary thyroid carcinoma (PTC) increases significantly after exposure of the head and neck region to ionizing radiation, yet we know neither the steps involved in malignant transformation of thyroid epithelium nor the specific carcinogenic mode of action of radiation. Such increased tumor frequency became most evident in children after the 1986 nuclear accident in Chernobyl, Ukraine. …To study the etiology of radiation-induced thyroid cancer, we formed an international consortium to investigate chromosomal changes and altered gene expression in cases of post-Chernobyl chPTC. Our approach is based on karyotyping of primary cultures established from chPTC specimens, establishment of cell lines and studies of genotype-phenotype relationships through high resolution chromosome analysis, DNA/cDNA micro-array studies, and mouse xenografts that test for tumorigenicity….

URL: http://www.osti.gov/bridge/purl.cover.jsp?purl=/901816-6SPdNw/