Targeting RET for thyroid cancer therapy

Title: Targeting RET for thyroid cancer therapy

Author: Lanzi, Cinzia / Cassinelli, Giuliana / Nicolini, Valentina / Zunino, Franco

Reference: Biochemical Pharmacology, 77 (3), p.297-309, Feb 2009

doi: 10.1016/j.bcp.2008.10.033

Keywords: Ret; Thyroid carcinoma; Tyrosine kinase inhibitor; Protein tyrosine kinase; Targeted therapy

Abstract: …of DNA damage in the thyroid follicular cells which…cases following the 1986 Chernobyl nuclear disaster. Whereas…prevalent in post-Chernobyl short-latency tumors…rearrangements confer neoplastic thyroid cells with distinct…be applied in thyroid cancer [13] , should provide…

URL: http://www.sciencedirect.com/science/article/pii/S0006295208007521