The effects of environmental low-dose irradiation on tolerance to chemotherapeutic agents.
Title: The effects of environmental low-dose irradiation on tolerance to chemotherapeutic agents.
Author: Howell, Eric K.; Gaschak, Sergey P.; Griffith, Kenneth D. W.; Rodgers, Brenda E.
Reference: Environmental Toxicology & Chemistry. Mar2011, Vol. 30 Issue 3, p640-649. 10p.
doi: 10.1002/etc.423.
Keywords: Chernobyl; Chemotherapy; Low-dose radiation; Radio-adaptation; Apodemus flavicollis
Abstract: The nuclear disaster at Chernobyl, Ukraine, in April of 1986 continues to impact the environment on many different levels. Studies of epidemiological, environmental, and genetic impacts have been prolific since the accident, revealing interesting results concerning the effects of radiation. The long-tailed field mouse, Apodemus flavicollis, was collected from distinct localities near the Chernobyl site and evaluated based on in vivo responses to the current clinically employed chemotherapeutic agents bleomycin (BLM) and vinblastine (VBL), as well as the immune modulator lipopolysaccharide (LPS). Maximum tolerable doses of three different cancer drugs were administered to the rodents from three different lifestyles: native mice living and reproducing in a radioactive environment, native mice living and reproducing in an uncontaminated region, and laboratory-reared mice ( Mus musculus BALB/c) with a known sensitivity to the chemical agents tested.
URL: http://onlinelibrary.wiley.com/doi/10.1002/etc.423/abstract
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