Thyroid cancer In children and adolescents In Ukraine and Its morphological characteristics following the Chornobyl accident.
Title: Thyroid cancer In children and adolescents In Ukraine and Its morphological characteristics following the Chornobyl accident.
Author: Bogdanova Т. I.
Reference: Dissertation for the degree of Doctor of Biological Science; speciality 14.01.14 – biological endocrinology; V.P.Komlssa-renko Institute of Endocrinology and Metabolism of the Academy of Medical Sciences of Ukraine, Kylv. 1996.
Abstract: Forty scientific papers containing the data on dynamics of thyroid cancer in children and adolescents in Ukraine following the Chernobyl accident. Its morphological (light and electromlcroscoplc. lmmunohlstochemlcal) characteristics are defended. A significant Increase In the thyroid cancer Incidence In children has been observed since 1990, particularly in the most contaminated areas. A solld-folllcular variant of papillary carcinoma was Identified as the most specific for post-Chernobyl cancers In children and adolescents. These tumours are characterised by highly Invasive properties, pronounced Immunoposltlve reaction to various oncogenes and growth factors which cause their aggressive biological behavior, with high incidence of regional and distant metastases. An increase In relative risk of the development of this variant of papillary carcinoma in children has been revealed, this depending upon the thyroid radiation dose during the Chernobyl accident, which proves the radiation genesis of the tumours studied.
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