カテゴリー「thyroid cancer」
Title: Re-evaluation of thyroid doses in Russia after the Chernobyl accident
Author: Stepanenko, Valery F / Gavrilin, Yuri I / Khrouch, Valery T / Shinkarev, Sergey M / Hoshi, Masaharu / Iaskova, Elena K / Kondrashov, Alexey E / (…) / Rivkind, Nikolay B
Reference: International Congress Series, 1234, p.321-328, May 2002
doi: 10.1016/S0531-5131(01)00621-5
Keywords: Chernobyl accident; I-131; Thyroid dose; Individual dosimetry
Abstract: Immediately after the Chernobyl accident, the team of Medical Radiological Research Center (MRRC) specialists carried out wide-scale measurements of iodine-131 content in the thyroid gland of 27 887 inhabitants of the Kaluga region. This initial information was presented only as official reports to governmental structures. Similar work was done by local specialists for 1441 inhabitants of the Bryansk region. The data of direct measurements provided us the basis for further individual thyroid dose estimations, where we exploited the developed model and personal interviews.This paper presents the results of updated dose evaluations, including the additional factors, such as dynamics of fallout and data on the pasture period…
URL: http://www.sciencedirect.com/science/article/pii/S0531513101006215
Title: 131 I Dose-Dependent Thyroid Autoimmune Disorders in Children Living around Chernobyl
Author: Vykhovanets, Eugene V. / Chernyshov, Victor P. / Slukvin, Igor I. / Antipkin, Yury G. / Vasyuk, Alexander N. / Klimenko, Helen F. / Strauss, Kenneth W
Reference: Clinical Immunology and Immunopathology, 84 (3), p.251-259, Sep 1997
doi: 10.1006/clin.1997.4379
Abstract: We assessed the major lymphocyte subsets in the peripheral blood, thyroid ultrasonography, levels of serum autoantibodies to thyroglobulin (AbTg), thyroid hormones, and thyroid-stimulating hormone (TSH) in 53 children without any chronic diseases living continuously around Chernobyl. The subjects ranged in age from 7 to 14 years and had different doses of131I to their thyroid. Healthy children living on noncontaminated areas were assessed as controls….
URL: http://www.sciencedirect.com/science/article/pii/S0090122997943798
Title: Thyroid cancer in children in Belarus: ascertainment bias?
Author: Averkin, JuriI. / Abelin, Theodor / Bleuer, JürgP.
Reference: The Lancet, 346 (8984), p.1223-1224, Nov 1995
doi: 10.1016/S0140-6736(95)92924-X
Abstract: …of childhood thyroid cancer after the Chernobyl accident…Belarus after the Chernobyl accident were Figure: Thyroid cancer in Belarus…Baverstock KF. Thyroid cancer in children in Belarus after Chernobyl Wld Hlth Statist…
URL: http://www.sciencedirect.com/science/article/pii/S014067369592924X
Title: Teratogen Update: Radiation and Chernobyl FRANK P. CASTRONOVO JR.*…
Author: FRANK P. CASTRONOVO JR.*
Reference: [PDF-54K]Feb 2008
Abstract: The 1986 nuclear reactor accident at Chernobyl caused nonuniform radiocontamination of air and land, primarily within regions of the former Soviet Union and Western Europe. .. Radioiodine (I-131) caused thyroid cancer in young children in portions of Belarus, the Ukraine, and Russia. It is not known but very possible that I-131 fetal thyroid exposure contributed to this observation… Occasional positive teratogenic studies in less contaminated regions of Western Europe are suspect because of the low radiation doses received. There is no substantive proof regarding radiation-induced teratogenic effects from the Chernobyl accident. Teratology 60:100–106, 1999.
URL: http://teratology.org/updates/60pg100.pdf
Title: New Directions in the Treatment of Thyroid Cancer
Author: You, Y. Nancy / Lakhani, Vipul / Wells, Samuel A., Jr
Reference: Journal of the American College of Surgeons, 205 (4 Supplement), p.S45-S48, Oct 2007
doi: 10.1016/j.jamcollsurg.2007.06.323
Abstract: …oncogenesis of several thyroid cancers. Gain-of-function…patients with papillary thyroid cancer (PTC) have chromosomal…form of the receptor in thyroid cells. These chromosomal…those linked with the Chernobyl accident) and in sporadic…
URL: http://www.sciencedirect.com/science/article/pii/S1072751507011775
Title: Gene rearrangements in thyroid carcinomas after irradiation during childhood: lessons from the Chernobyl reactor accident
Author: Rabes, Hartmut M
Reference: International Congress Series, 1234, p.193-200, May 2002
doi: 10.1016/S0531-5131(01)00608-2
Keywords: Papillary thyroid carcinoma; Gene rearrangement; DNA breakpoints; Irradiation; RET
Abstract: Papillary thyroid carcinomas (PTC) developed with a high incidence in children and young adults who had been exposed to radioactive fallout in contaminated regions of Belarus after the Chernobyl reactor accident. They are informative for a molecular genetic analysis of radiation-induced PTC. In contrast to spontaneous PTC, a high prevalence of gene aberrations was found with rearrangements of the receptor tyrosine kinase gene RET in the majority of cases and a few NTRK1 rearrangements. In the rearranged form of RET, the transmembrane and extracellular parts are replaced by regulatory units of other genes….
URL: http://www.sciencedirect.com/science/article/pii/S0531513101006082
Title: Post-Chernobyl thyroid carcinoma in children
Author: Leenhardt, Laurence / Aurengo, André
Reference: Best Practice & Research Clinical Endocrinology & Metabolism, 14 (4), p.667-677, Dec 2000
doi: 10.1053/beem.2000.0109
Keywords: Chernobyl; accidents, radiation; children, thyroid carcinoma; thyroid neoplasms/*genetics; carcinoma, papillary/*genetics; molecular sequence data; mutation/*genetics; gene rearrangement; Ukraine; Belarus
Abstract: The dramatic increase in childhood thyroid carcinoma observed in Belarus and Ukraine as early as 4 years after the Chernobyl nuclear accident, is well recognized as being a consequence of exposure to radioactive iodine fallout. Uncertainties persist concerning the contamination and the dosimetric data. Thyroid nodule, cervical lymph nodes or systematic ultrasound thyroid screening in exposed children led to the diagnosis….
URL: http://www.sciencedirect.com/science/article/pii/S1521690X0090109X
Title: Scientific Facts on the Chernobyl Nuclear Accident
Reference: [PDF-328K]Mar 2012
Abstract: …UN Chernobyl Forum: “Chernobyl‘s legacy: Health…greenfacts.org/en/chernobyl/ This PDF Document is the…Introduction Where is Chernobyl? [see Annex 3, p…15 patients died from thyroid cancer, and it is roughly estimated…
URL: http://www.greenfacts.org/en/chernobyl/chernobyl-greenfacts.pdf
Title: Thyroid Cancer ATA Web Brochure
Reference: [PDF-962K]Jun 2012
Abstract: …X-rays, mammograms have not been shown to cause thyroid cancer. Thyroid cancer can also be caused by radioactive iodine released…nuclear disasters such as the 1986 accident at the Chernobyl power plant in Russia or the 2011 nuclear disaster…
URL: http://www.thyroid.org/wp-content/uploads/patients/brochures/ThyroidCancer_brochure.pdf
Title: Thyroid cancer after neck irradiation during childhood
Author: Kingston, Judith
Reference: The Lancet, 365 (9476), p.1986-1987, Jun 2005
doi: 10.1016/S0140-6736(05)66675-5
Abstract: …78% of all the secondary thyroid cancers. The paediatric thyroid gland appears to be particularly…increase (30-fold) of thyroid cancer in girls under the age of…radioactive fallout after the Chernobyl nuclear-reactor explosion…
URL:http://www.sciencedirect.com/science/article/pii/S0140673605666755
