カテゴリー「thyroid cancer」
Title: Childhood thyroid cancer since accident at Chernobyl
Author: Stsjazhko, V A / Tsyb, A F / Tronko, N D / Souchkevitch, G / Baverstock, K F
Reference: BMJ, 310 (6982), p.801-801, Mar 1995
doi: 10.1136/bmj.310.6982.801
Keywords:
Abstract: We wish to report on a meeting of scientists from the three countries most closely affected by the accident at Chernobyl and from the World Health Organisation to review the programme of screening for and diagnosis of childhood thyroid cancer undertaken since the accident in April 1986. While the central purpose of the screening programme was humanitarian, during the review some of the information compiled was deemed to be of scientific interest.
URL: http://www.bmj.com/content/310/6982/801.1
Title: Childhood thyroid cancer since accident at Chernobyl
Author: Sinnaeve, J / Chadwick, K H / Karaoglou, A
Reference: BMJ, 310 (6993), p.1538-1538, Jun 1995
doi: 10.1136/bmj.310.6993.1538
Keywords:
Abstract: The letter from representatives of the World Health Organisation and the three countries most affected by the accident at Chernobyl—Belarus, Russia, and the Ukraine—draws attention to the increasing number of thyroid tumours in children exposed to fallout from the accident. We endorse the comment that an international response to this unprecedented event is needed. Different countries have already reacted, and at least eight international actions on this issue are currently going on around the world. I wish to give some impression of the many international and bilateral efforts to provide medical help for the people affected by the Chernobyl accident, in addition to the …
URL: http://www.bmj.com/content/310/6993/1538.1
Title: 15 years after Chernobyl: new evidence of thyroid cancer
Author: Shibata, Yoshisada / Yamashita, Shunichi / Masyakin, Vladimir B / Panasyuk, Galina D / Nagataki, Shigenobu
Reference: The Lancet, 358 (9297), p.1965-1966, Dec 2001
doi: 10.1016/S0140-6736(01)06971-9
Keywords:
Abstract: The Chernobyl nuclear power plant accident happened on April 26, 1986. We investigated the cause of the striking increase in frequency of thyroid cancer in children who lived within a 150 km radius of Chernobyl and who were born before and after the accident. No thyroid cancer was seen in 9472 children born in 1987–89, whereas one and 31 thyroid cancers were recorded in 2409 children born April 27, 1986, to Dec 31, 1986, and 9720 born Jan 1, 1983, to April 26, 1986, respectively. Short-lived radioactive fallout caused by the Chernobyl accident probably induced thyroid cancer in children living near Chernobyl.
URL: http://scirus.com/srsapp/search?q=chernobyl+(thyroid+cancer)&t=all&fdt=0&tdt=2014&drill=yes&sort=0&p=30&nff=pdf
Title: Comparison of thyroid cancer incidence after the Chernobyl accident in Belarus and in Ukraine
Author: Jacob, Peter / Bogdanova, Tatiana I. / Buglova, Elena E. / Kenigsberg, Jacov E. / Tronko, Nikolay D.
Reference: International Congress Series, 1234, p.215-219, May 2002
doi: 10.1016/S0531-5131(01)00622-7
Keywords: Chernobyl; Thyroid cancer
Abstract: Data on thyroid cancer cases operated in the period 1986–1999 among those born in Belarus and in Ukraine during the period 1968–1985 are analysed. Whereas the dependence of the total number of thyroid cancer cases on time after exposure is similar in the two countries, there are obvious differences in the dependencies on age at operation and on age at exposure.
URL: http://www.sciencedirect.com/science/article/pii/S0531513101006227
Title: Summary of the 15-year observation of thyroid cancer among Ukrainian children after the Chernobyl accident
Author: Tronko, Nikolay D / Bogdanova, Tatiana I / Likhtarev, Ilya A / Kairo, Irina A / Shpak, Viktor I
Reference: International Congress Series, 1234, p.77-83, May 2002
doi: 10.1016/S0531-5131(01)00597-0
Keywords: Thyroid cancer; Children; Register; Exposure doses; Pathology
Abstract: According to the data of the clinico-morphological register of the Institute of Endocrinology and Metabolism in Ukraine, for the post-Chernobyl period in Ukraine (1986–2000), 472 cases of thyroid cancer have been reported in children who have been operated at the age of up to 15 years, among which, 431 were born before the Chernobyl accident, 11 were “in utero” at the time of the accident, and 30 were born after the Chernobyl accident. The largest number of cases (57) has been reported in 1996, which made up 0.57 per 100 000 children aged 0–14, and exceeded by 11.4 times the average pre-Chernobyl incidence rate (0.05) in this age group. The highest incidence rate has been reported in six regions of Ukraine which have been the most contaminated by iodine radionuclides (Kiev, Chernigov, Zhitomir, Rovno, Cherkassy regions, and Kiev City). …
URL: http://www.sciencedirect.com/science/article/pii/S0531513101005970
Title: Molecular epidemiology of childhood thyroid cancer around Chernobyl
Author: Yamashita, Shunichi / Shibata, Yoshisada / Namba, Hiroyuki / Takamura, Noboru / Saenko, Vladimir,
Reference: International Congress Series, 1236, p.201-205, Jul 2002
doi: 10.1016/S0531-5131(01)00855-X
Keywords: Chernobyl; Screening ; Thyroid cancer; Gene rearrangement; Signal transduction
Abstract: …The comparative study of thyroid diseases demonstrates the likelihood of short-lived radioactive iodine on thyroid cancer in the children born before the Chernobyl accident. Next, at the standpoint of recent molecular analysis of thyroid carcinogenesis, many reports now indicate evidence of a high incidence of ret/PTC gene rearrangement in childhood thyroid cancer tissues. Besides ret/PTC gene rearrangement, the disturbance of the response of intracellular signal transduction to radiation exposure is also important in thyroid cells, and results demonstrate that radiation exposure could cause abnormal thyroid cell proliferation specifically through constitutive activation of intracellular target molecules via membrane lipid breakdown, and subsequently disturb the apoptosis-prone pathway. …Therefore, the late effect of radiation, even in the lower dose on the human thyroid glands, should be monitored carefully for the radiation-sensitive vulnerable group for a longer period, especially around Chernobyl.
URL: http://www.sciencedirect.com/science/article/pii/S053151310100855X
Title: Thyroid cancer among children and adolescents of Belarus exposed due to the Chernobyl accident: dose and risk assessment
Author: Kenigsberg, Jacov E / Buglova, Elena E / Kruk, Julianna E / Golovneva, Alla L
Reference: International Congress Series, 1234, p.293-300, May 2002
doi: 10.1016/S0531-5131(01)00618-5
Keywords: Thyroid cancer; Chernobyl accident; Assessment
Abstract: …Number of thyroid cancer cases after the Chernobyl accident…consequences of the Chernobyl accident among…radiation-induced thyroid cancer. There is…accident at the Chernobyl Nuclear Power Plant, thyroid cancer incidence…
URL: http://scirus.com/srsapp/search?q=chernobyl+(thyroid+cancer)&t=all&fdt=0&tdt=2014&drill=yes&sort=0&p=30&nff=pdf
Title: : Radioiodine-induced thyroid cancer: Studies in the aftermath of the accident at Chernobyl
Author Robbins, Jacob / Schneider, Arthur B
Reference: Trends in Endocrinology & Metabolism, 9 (3), p.87-94, Apr 1998
doi: 10.1016/S1043-2760(98)00024-1
Keywords: radiation; thyroid cancer; thyroid oncogenes; radioiodine; Chernobyl cancer
Abstract: While a great deal is known about the relationship between external radiation exposure and thyroid cancer, much less is known about the oncogenic effects of internal radiation exposure from isotopes of iodine. The accident at the Chernobyl nuclear power plant released massive quantities of radioiodine isotopes into the atmosphere. The large number of ensuing thyroid cancers in exposed children leaves little doubt that these malignancies have occurred as a result of the accident. However, carefully planned epidemiological studies are needed to confirm that these are due predominantly to I-131 exposure, to determine the dose-response relationship, to monitor for continuing effects and to evaluate other contributing factors. Preliminary evidence indicates that there is a distinct pattern of somatic genetic changes in the thyroid cancers from the Chernobyl area.
URL: http://www.sciencedirect.com/science/article/pii/S1043276098000241
Title: Ten-year Chernobyl aid programmes of the Otto Hug Strahleninstitut-MHM: treatment and research projects on thyroid cancer in Belarus
Author: Lengfelder, Edmund / Demidchik, Evgueni P. / Demidchik, Yuri E. / Sidorov, Yury D. / Gedrevich, Zigmund E. / Birukova, Ludmila W. / Gamolina, Larisa I. / (…) / Frenzel, Christine
Reference: International Congress Series, 1234, p.201-204, May 2002
doi: 10.1016/S0531-5131(01)00609-4
Keywords: Chernobyl; Thyroid cancer; Thyroid pathology; Medical care; Tissue bank
Abstract: The unexpected serious increase in the incidence of thyroid cancer following the reactor accident in Chernobyl led to considerable research efforts from abroad and the support of Belarus in order to mitigate these health problems. In 1991, the Otto Hug Strahleninstitut-MHM (Otto Hug Radiation Institute), a German non-governmental medical–scientific charity organization, started several long-term aid programmes and treatment and research projects on thyroid cancer and other diseases of this organ. Since 1993, the project “Thyroid Center Gomel” had more than 70 000 patients from this region for the diagnosis and treatment of thyroid diseases including cancer. …More than 6500 thyroid tumours were diagnosed, preparing over 30 000 pathological slides. In 1997, the project of “Radioiodine Therapy” started in Gomel, giving treatment to more than 450 patients since that time. …
URL:http://www.sciencedirect.com/science/article/pii/S0531513101006094
Title: Joint Belarus/Russia/EU/IARC/SMFH case–control studies of thyroid cancer in young people following the Chernobyl accident
Author: Cardis, Elisabeth / Ivanov, Victor K / Kesminiene, Ausrele / Malakhova, Irina V / Shibata, Yoshisada / Tenet, Vanessa / on behalf of the joint study group,
Reference: International Congress Series, 1234, p.105-113, May 2002
doi: 10.1016/S0531-5131(01)00600-8
Keywords: Thyroid cancer; Radiation risk; Risk modifiers; Iodine deficiency; Genetic predisposition; Children; Chernobyl
Abstract: In 1996, following several years of collaborative international studies of the consequences of the Chernobyl accident, a number of groups proposed to carry out case–control studies of thyroid cancer among young people in contaminated territories of Belarus and Russia. … The collaboration has resulted in the collection of one of the largest sources of data on thyroid cancer risk in children, adolescents and young adults exposed to ionising radiation. Results from this work are likely to have important implications for radiation protection in general, as well as for public health actions among exposed populations in the CIS.
URL: http://www.sciencedirect.com/science/article/pii/S0531513101006008
