Comparative Morphological Analysis of Papillary Thyroid Carcinoma in Children and Adolescents Born before and after Chernobyl Accident

Title: Comparative Morphological Analysis of Papillary Thyroid Carcinoma in Children and Adolescents Born before and after Chernobyl Accident

Author: Abrosimov A. Yu.

Reference: Medical Radiological Research Center of Russian Academy of Medical Sciences, 4 Korolev str., Obninsk, Kaluga district, 249036 Russia

ISSN: 0025-8334

Keywords: THYROID,   RADIOGENIC AND SPORADIC PAPILLARY CARCINOMA,   CHILDREN AND ADOLESCENTS,   CHERNOBYL ACCIDENT

Abstract: Purpose: To elaborate comparative morphological analysis of radiogenic and sporadic papillary thyroid carcinoma in children and adolescents bom before and after Chernobyl accident and living in the radionuclide contaminated regions of the Russian Federation. Material and methods: Histological sections of papillary carcinoma and medical records from I8O children (under 15 years old) and adolescents (from 15 to 19 years) living in Bryansk, Kaluga, Oryol and Tula regions of Russia have been examined. The first group of radiogenic cancer cases includes 130 patients whose thyroid might be exposed after the accident. The second group of sporadic tumors includes 50 patients bom since the end of January 19S7 and whose thyroid exposure to radioiodine becomes negligible. A comparison between two groups via prevalence of different histological types of papillary carcinoma and other morphological features of tumor growth has been performed. Results;The male/female ratio in the first group is 1/1.5 comparing to the second group where it is 1/3.2. The average size of tumors in the first group is higher than that in the second one (14.6+1.0 mm vs. 11.4+0.8 mm), but difference is not quite significant (p-0.06). The differences between higher extent of tumor stromal fibrosis (52.3 %) and extent of cxtrathyroid invasion (23.8 %) of tumors in the first group comparing to the second group (28.0 % and 8.0 % respectively) are statistically significant (p<0.01 and р=0.02 respectively). No differences ‘between two groups have been revealed in the prevalence of various histological types of papillary carcinoma. Conclusion: Radiogenic and sporadic papillary carcinomas have no specific types of histological architecture (histological variants). Twо groups differ from each other by the male/female ratio (females are significantly prevailing in the sporadic group), as well as by the extent of stromal fibrotic response and extent of extrathyroid invasive growth that could be revealed more often in the group of radiogenic papillary thyroid carcinomas.

URL: http://elibrary.ru/item.asp?id=10019508

UN CONFERENCE “PROJECT CHERNOBYL. LIFE IN CONDITIONS OF RADIATION AFTER CHERNOBYL DISASTER: Treatment of thyroid cancer of patients in the era of health care reform “

Author: A.F. Romanchishen

Reference: conference material, article in journal «Bulletin of Surgery, named after I.I. Grekov”, St. Petersburg, 2010

ISSN: 0042-4625

Keywords: Chernobyl catastrophe, thyroid cancer

URL: http://elibrary.ru/item.asp?id=13092744

Thyroid cancer in children and adults of the Belgorod region, during the 15 years after the Chernobyl Accident

Author: T.P. Golibets, B.S. Kobalenko

Reference: article in journal “Palliative medicine and rehabilitation”, Moscow, 2005

ISSN: 2079-4193

URL: http://elibrary.ru/item.asp?id=14778264

Hygienic problems of reducing the remote medical effects of exposure on population at nuclear accidents (on the materials of the Chernobyl accident)

Author: N.K. Shandala

Reference: Abstract, Moscow 1997, HAC Russia 14.00.07

Keywords: hygiene, reduce negative effect

Abstract: Aim of research: Substantiation of hygienic bases to reduce remote negative medical effects of exposure on population at large-scale communal nuclear accident.

URL: http://medical-diss.com/medicina/gigenicheskie-problemy-umensheniya-otdalennyh-meditsinskih-posledstviy-oblucheniya-naseleniya-pri-atomnyh-avariyah-na-mat

Radiation-hygienic value of sources and population exposure doses of the 30-km zone, after the Chernobyl accident

Author: V.S. Repin

Reference: Abstract, Kiev, 1995 HAC Russia 14.01.02

Keywords: evacuees, exposure analyses, doses

Abstract: Retrospective evaluation of individual and collective doses, as well as analyses of radiation-hygienic value of the factors of external and internal exposures on the evacuees from the 30-km zone of the Chernobyl NPP.
URL: http://medical-diss.com/medicina/radiatsionno-gigienicheskoe-znachenie-istochnikov-i-doz-oblucheniya-naseleniya-30-km-zony-posle-avarii-na-chaes

Hygienic substantiation of prevention of health problems among students living in radiation-affected areas

Author: M.G. Guryanova

Reference: Abstract of Moscow 2006 WAC Russia 14.00.07

Keywords: preventive measures, detection, mental, physical

Abstract: Science-based approach of early detection and prevention of mental and physical health destruction of young people living in environmental conditions of radioactive contamination.
URL: http://medical-diss.com/medicina/gigienicheskoe-obosnovanie-profilaktiki-narusheniy-zdorovya-studentov-iz-radiatsionno-neblagopoluchnyh-rayonov

Radiosensitivity to low doses of ionizing radiation of children as a basis for the development of somatic diseases

Author: A.E. Sipyagina

Reference: Abstract, Moscow 2003 WAC Russia 14.00.09

Keywords: radiosensitivity, remote period, preventive measures

Abstract: The purpose of the study is to prove the existence of radiosensitivity, to develop its diagnostic criteria and show the value in the formation of long-term (remote) radiation-induced effects (diseases); to justify system of dispensary and preventive measures aimed at correcting changes and preventing progression of disease in children exposed to low-intensity-radiation impact as result of the accident at the Chernobyl nuclear power plant.

Dissertation materials are used in the preparation for the orders of Ministry of Health of the Russian Federation № 171 dated 26.07.1993 “On the procedure of specialized medical examination for persons exposed to radiation as result of the Chernobyl catastrophe», № 100 dated 04.08.1997 “On the diagnosis and treatment of patients with thyroid cancer, born between 1968 to 1987, exposed to radiation as result of the Chernobyl accident. ”
URL: http://medical-diss.com/medicina/radiochuvstvitelnost-k-malym-dozam-ioniziruyuschego-izlucheniya-u-detey-kak-osnova-razvitiya-somaticheskih-zabolevaniy

Comparative assessment of risk caused by exposure to the population of the Oryol region, on various sources of ionizing radiation

Author: V.G. Simonova

Reference: Moscow 2007 WAC Russia 14.00.07

Keywords: public interest, social consequences, medicine, comparative risk assessment

Abstract: Even 20 years after the accident at the Chernobyl nuclear power plant, public interest in the issues of radiation safety of the population and the personnel, working with ionizing radiation sources, (IRS) remains unabated. Special interest, with respect to the effects of radiation on human health and the environment, is the medical and social consequences of this exposure.

The aim of the work is to establish comparative risk assessment of the impact on the population, living in Oryol region, by various radiation sources.
URL: http://medical-diss.com/medicina/sravnitelnaya-otsenka-riska-ot-vozdeystviya-na-naseleniya-orlovskoy-obl-razlichnyh-istochnikov-ioniziruyuschego-izlucheni

Comprehensive analysis of incidence of malignant tumors in the population of Belgorod region during the post-Chernobyl period

Author: B.S. Kovalenko

Reference: Obninsk 2005 Russia 14.00.19

Keywords: sex, age, period, 1981-2000

Abstract: External test to analyze incidence of the population living in Belgorod region, for the 20-year period (1981-2000), according to sex, age and period under observation (1981-1985., 1986-1990., 1991-1995., 1996-2000 .), including an assessment of the role of environmental factors that could have an impact on the growth of cancer rates in the post-Chernobyl period.

URL: http://medical-diss.com/medicina/kompleksnyy-analiz-zabolevaemosti-zlokachestvennymi-novoobrazovaniyami-naseleniya-belgorodskoy-oblasti-v-postchernobylsko

Risk factors and possible mechanisms for the formation of thyroid pathology in children

Author: T.V. Blokhina

Reference: Abstract ,Tomsk 2005 WAC Russia 14.00.09

Keywords: risk factors, tireopaty

Abstract: Objective: The study of major risk factors and their role in the mechanism of thyroid disease in children. Estimation of the prevalence of Tireopaty in the studied population, and the effectiveness of correction of detected violations.

URL: http://medical-diss.com/medicina/faktory-riska-i-vozmozhnye-mehanizmy-formirovaniya-tireoidnoy-patologii-v-detskom-vozraste