SPECIAL REPORTS seen in the thyroid.

Title: SPECIAL REPORTS seen in the thyroid.

Author: Fred A. Mettler

Reference: [PDF-287K]Jul 2007 SPECIAL REPORTS: HEALTH EFFECTS
Keywords:

Abstract: …the 1996 Chernobyl Conference…cerns about thyroid problems…nodules, and cancer. In 1990…the 1996 Chernobyl Conference…increase in thyroid nodules…leukaemia and cancer. A 1990…related to thyroid cancer and leukaemia…International Chernobyl Project represented…

URL: http://www.iaea.org/Publications/Magazines/Bulletin/Bull383/38305893335.pdf

Dose-Dependent Generation of RET/PTC in Human Thyroid Cells after in Vitro Exposure to -Radiation: A Model of Carcinogenic Chromosomal Rearrangement Induced by Ionizing Radiation.

Title: Dose-Dependent Generation of RET/PTC in Human Thyroid Cells after in Vitro Exposure to  -Radiation: A Model of Carcinogenic Chromosomal Rearrangement Induced by Ionizing Radiation.

Author: Christy M. Caudill, Zhaowen Zhu, Raffaele Ciampi, James R. Stringer, and Yuri E. Nikiforov

Departments of Pathology and Laboratory Medicine and Molecular Genetics, University

Reference: [PDF-201K]Jun 2009 The Journal of Clinical Endocrinology & Metabolism 90(4):2364–2369
doi: 10.1210/jc.2004-1811

Keywords:

Abstract: …countries (5, 6). The risk of thyroid cancer correlated with proximity to Chernobyl and thyroid dose and in some areas was found…radiation exposure. In this respect, thyroid cancer in children after the Chernobyl accident represents the most thoroughly…

URL: http://path.upmc.edu/people/ynlab/Publication%20PDFs/Zhu2005JournalofClincialEndoandMeta.pdf

Radiation therapy in childhood cancer

Title: Radiation therapy in childhood cancer
Author: Ruble, Kathy / Kelly, Katherine Patterson

Reference: Seminars in Oncology Nursing, 15 (4), p.292-302, Nov 1999

doi: 10.1016/S0749-2081(99)80058-8

Keywords: childhood cancer,

Abstract: …FIGURE 1. Types of childhood cancer. Data from Gurney et al…nurses caring for children with cancer. In general, the degree of…is filled with reports from Chernobyl. Along a similar line, the…the treatment of child- hood cancer, more and more survivors are…

URL: http://www.sciencedirect.com/science/article/pii/S0749208199800588

Testable hypotheses for cancer risks near nuclear facilities

Title: Testable hypotheses for cancer risks near nuclear facilities

Author: Steve Wing

Reference: [PDF-41K]Aug 2011 Statement to the Nuclear and Radiation Studies Board of the National Academies

Keywords:

Abstract: …example, a child diagnosed with cancer at age 4 who lived near a nuclear…could help to improve a study of cancer in populations near nuclear facilities…for studies of radioiodine and thyroid cancer near Chernobyl and Hanford, WA.16, 17 Consideration…

URL: http://dels.nas.edu/resources/static-assets/nrsb/miscellaneous/Wing.pdf

Medical management of the acute radiation syndrome

Title: Medical management of the acute radiation syndrome

Author: López, Mario / Martín, Margarita

Reference: Reports of Practical Oncology & Radiotherapy, 16 (4), p.138-146, Jul 2011

doi: 10.1016/j.rpor.2011.05.001

Keywords: Acute radiation syndrome; Radiation injury; Radiation exposure; Nuclear accident

Abstract: This review will focus on the clinical aspects of the ARS, using the European triage system (METREPOL) to evaluate the severity of radiation injury, and scoring groups of patients for the general and specific management of the syndrome.

…concentrations for miles around Chernobyl following the accident…Radioiodines are known from Chernobyl data to cause thyroid injury and to be carcinogenic…binding sites within the thyroid and inhibits incorporation…exposed population in Chernobyl. 6 Phases of acute…

URL: http://www.sciencedirect.com/science/article/pii/S1507136711000642

Acute myeloid leukemia presenting in a mother and daughter pair with the identical acquired karyotypic abnormality consisting of inversion 3q21q26 and monosomy 7: a review of possible mechanisms

Title: Acute myeloid leukemia presenting in a mother and daughter pair with the identical acquired karyotypic abnormality consisting of inversion 3q21q26 and monosomy 7: a review of possible mechanisms
Author: Lawrie, Alastair / Stevenson, David A.J. / Doig, Tamasin N. / Vickers, Mark A. / Culligan, Dominic J

Reference: Cancer Genetics, 205 (11), p.599-602, Nov 2012

doi: 10.1016/j.cancergen.2012.09.001

Keywords: Myeloid; hereditary; monosomy 7; inversion 3q21

Abstract: The 3q21q26 inversion is associated with both myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML), often in association with monosomy 7. In this report, we present a young woman and her mother, both diagnosed with AML, exhibiting similar morphological and identical cytogenetic features. AML with abnormalities of chromosome 3q is often characterized by abnormal megakaryopoeisis and diabetes insipidus, and both were seen in these cases. To our knowledge, this is the first report of familial aggregation of AML displaying an inversion of chromosome 3q and monosomy 7. We discuss possible mechanisms for the development of familial AML with identical karyotypic abnormalities and the link between 3q aberrations and monosomy 7.

…within the National Cancer Research Institute…released as a result of the Chernobyl accident in 1986, at…Increases in childhood thyroid cancer were noted in studies…exposed to radiation from Chernobyl is much less strong…

URL: http://www.sciencedirect.com/science/article/pii/S2210776212002323

ICRP PUBLICATION 118: ICRP Statement on Tissue Reactions and Early and Late Effects of Radiation in Normal Tissues and Organs – Threshold Doses for Tissue Reactions in a Radiation Protection Context

Title: ICRP PUBLICATION 118: ICRP Statement on Tissue Reactions and Early and Late Effects of Radiation in Normal Tissues and Organs – Threshold Doses for Tissue Reactions in a Radiation Protection Context

Author: Stewart, F.A. / Akleyev, A.V. / Hauer-Jensen, M. / Hendry, J.H. / Kleiman, N.J. / MacVittie, T.J. / Aleman, B.M. / (…) /
Reference: Annals of the ICRP, 41 (1-2), p.1-322, Feb 2012
doi: 10.1016/j.icrp.2012.02.001
Keywords:
Abstract: This report provides a review of early and late effects of radiation in normal tissues and organs with respect to radiation protection. It was instigated following a recommendation in Publication 103 (ICRP, 2007), and it provides updated estimates of ‘practical’ threshold doses for tissue injury defined at the level of 1% incidence. Estimates are given for morbidity and mortality endpoints in all organ systems following acute, fractionated, or chronic exposure. The organ systems comprise the haematopoietic, immune, reproductive, circulatory, respiratory, musculoskeletal, endocrine, and nervous systems; the digestive and urinary tracts; the skin; and the eye….
 
…training.seer.cancer.gov…1992) Nuclear reactor Chernobyl, 1986 n = 214 with exposure…Agency for Research on Cancer; ERR, excess…workers Jacobson (2005) Chernobyl…spermatogenesis from damage by cancer chemotherapy or radiotherapy…

URL: http://www.sciencedirect.com/science/article/pii/S0146645312000024

95/00818 The Chernobyl papers. Volume 1: Doses to the Soviet population and early health effects studies

Title: 95/00818 The Chernobyl papers. Volume 1: Doses to the Soviet population and early health effects studies
Author:

Reference: Fuel and Energy Abstracts, 36 (1), p.48, Jan 1995

doi: 10.1016/0140-6701(95)96073-2

Keywords:

Abstract: …the population after the Chernobyl accident; Biological dosimetry…syndrome in victims of the Chernobyl accident; and the Thyroid cancer in children of the Belarus Republic after the Chernobyl accident. 95/00819 Clean…

URL: http://www.sciencedirect.com/science/article/pii/0140670195960732

Chapter 78 – Effect of Lifelong Iodine Supplementation

Title: Chapter 78 – Effect of Lifelong Iodine Supplementation

Author: Berg, Gertrud / Nyström, Ernst

Reference: Comprehensive Handbook of Iodine, Jan 2009

ISBN:9780123741356

Keywords:

Abstract: This chapter describes the consequences of lifelong iodine supplementation concentrating on adults. The results of studies of various aspects of iodine metabolism and thyroid disease in Sweden have been summarized. Sweden has had iodine supplementation since 1936; thus, an adult in Sweden today has experienced lifelong exposure to iodine. The uptake of iodine in the thyroid gland is lower than in a Swedish population studied 45 years earlier, showing the long-term adaptation to an environment higher in iodine. These figures correspond to an intake of iodine of about 260 μg/day in 2000 compared to 100 μg/day in 1955. The prevalence of goiter is 7% in adults in western
Sweden, which is lower than in areas with low iodine intake. The prevalence of thyroid autoimmune disease may be slightly higher than in populations with a low iodine intake. Thyroid cancer incidence has been stable for the period 1971–2006. Intrathyroid iodine levels may vary in a population, which has been iodine-sufficient for a long period. Most of the studies were performed in the small community of Mölnlycke in western Sweden where the population studied consists of a fairly homogeneous group that has been stationary in the region.

…incidence of thyroid cancer rose from 2.6…promoting effect on thyroid cancer development after the Chernobyl accident ( Shakhtarin…Sweden after the Chernobyl accident. Nonetheless…been observed in thyroid cancer incidence among…

URL: http://www.sciencedirect.com/science/article/pii/B9780123741356000789

Sixty years of follow-up of Hiroshima and Nagasaki survivors: Current progress in molecular epidemiology studies

Title: Sixty years of follow-up of Hiroshima and Nagasaki survivors: Current progress in molecular epidemiology studies
Author: Nakachi, Kei / Hayashi, Tomonori / Hamatani, Kiyohiro / Eguchi, Hidetaka / Kusunoki, Yoichiro

Reference: Mutation Research/Reviews in Mutation Research, 659 (1-2), p.109-117, Jul 2008
doi: 10.1016/j.mrrev.2008.02.001

Keywords: Radiation; Atomic-bomb survivors; Somatic mutation; Oxidative stress; Colorectal carcinogenesis; Microsatellite instability; Thyroid carcinogenesis

Abstract: This article provides an overview of the on-going molecular epidemiology studies among atomic-bomb survivors conducted at the Radiation Effects Research Foundation in Japan. The focus is on: (a) inter-individual variations in sensitivity to radiation-induced somatic mutations (glycophorin A (GPA) mutations) and their potential relevance to differences in susceptibility to radiation-related cancers and (b) the role of specific mutations/rearrangements in radiation-induced thyroid and colorectal cancers. The glycophorin A mutant fractions showed large differences between the survivors at each of the estimated bone marrow doses. Of note is the finding at doses ≥1 Gy; that the slope of the mutant fraction was significantly higher in the ‘cancer group’ than in the ‘non-cancer group’. This study provided the basis for validating the use of γH2AX and reticulocyte micronucleus assays for evaluating radiosensitivity differences and genetic instability, respectively, in our studies in the coming years. Preliminary results from our molecular oncology studies on adult-onset papillary thyroid cancer provide evidence for the induction of RET/PTC rearrangements and BRAF point mutation (both known to be early stage events in adult-onset papillary thyroid cancer) but with a difference: cases associated with the rearrangements were more frequent at high doses, and developed sooner than those with BRAF mutation. In the case of colorectal cancer, the results suggest that radiation exposure might influence microsatellite instability (MSI) status through MSI-related epigenetic and genetic alterations—processes that might occur in the early stage of colorectal carcinogenesis.

…spontaneous thyroid cancer in the Japanese…variant papillary thyroid cancer was not found in…although this cancer has been frequently…observed among post-Chernobyl children. A major…event in papillary thyroid carcinogenesis is…

URL: http://www.sciencedirect.com/science/article/pii/S1383574208000318