DNA damage evaluated by alkaline single cell gel electrophoresis (SCGE) in children of Chernobyl, 10 years after the disaster

Title: DNA damage evaluated by alkaline single cell gel electrophoresis (SCGE) in children of Chernobyl, 10 years after the disaster

Author: Frenzilli, G / Bosco, E / Antonelli, A / Panasiuk, G / Barale, R
Reference: Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 491 (1-2), p.139-149, Apr 2001

doi: 10.1016/S1383-5718(01)00136-X

Keywords: Single cell gel electrophoresis; Human leukocytes; DNA damage; Bleomycin; Clastogenic factors

Abstract: Using the alkaline single cell gel electrophoresis (Comet) assay, the extent of DNA damage was evaluated in leukocytes of 43 Belarussian children (16 healthy and 27 affected by thyroid cancer). Thirty-nine healthy children from Pisa (Italy) were enrolled in the study as controls. In addition to basal levels of DNA damage, leukocytes were treated in vitro with bleomycin (BLM), a radiomimetic drug, to evaluate a possible adaptive response in different groups of children….

URL: http://www.sciencedirect.com/science/article/pii/S138357180100136X

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