MOLECULAR CYTOGENETIC STUDIESON CHILDHOOD THYROID TUMOURS FROM BELARUS

Title: MOLECULAR CYTOGENETIC STUDIESON CHILDHOOD THYROID TUMOURS FROM BELARUS

Author: H. Zitzelsberger, J. Smida, K. Salassidis, L. Heiber, M. Bauchinger

Reference: Zitzelsberger et al. / International journal of radiation medicine  1999, 3–4 (3–4): 17–19

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Abstract: Since 1992, tissue specimens from 264 childhood thyroid tumours from Belarus were received by the Institute of Radiobiology at GSF. For control, tumour samples from Belarussian adults, papillary carcinomas without radiation history and secondary thyroid tumours developed after radiotherapy were also collected. Based on this tissue and cell culture collection, several molecular cytogenetic studies were carried out investigating aberrations in subgroups of these tumours at the chromosomal and molecular level. These studies include the quantification of chromosomal aberrations by FISH-painting (Lehmann L. et al., 1996), G-banding and breakpoint analyses of chromosomal aberrations (Lehmann L. et al., 1997; Zitzelsberger H. et al., in press), analyses of p53 mutations (Smida J. et al., 1997) and RET rearrangements (Smida J. et al., in press) and an expression profiling of activated tyrosine kinase genes. This presentation focuses on cytogenetic studies and the investigation of RET rearrangements

URL: http://www.physiciansofchernobyl.org.ua/magazine/PDFS/3-4_1999/3_3_99_61.pdf

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