MORPHOMETRIC NEUROVISUAL CHARACTERISTIC OF ORGANIC BRAIN DAMAGE IN REMOTE PERIOD OF EXPOSURE TO IONIZING RADIATION AS A RESULT OF THE CHERNOBYL ACCIDENT
Author: M.A. Bomko
Reference: Український медичний часопис (Ukrainian Medical Magazine), 2004
Keywords: ionizing radiation, organic brain damage, magnetic-resonance imaging, morphometry
Abstract: The goal of the study was to determine the distinctive features of organic brain damage in remote period of exposure to ionizing radiation as a result of the Chernobyl accident on the basis of morphometric analysis of cerebral magnetic-resonance images (MRI). There were examined 79 clean-up workers of the consequences of the Chernobyl accident with organic mental disorders following exposure to ionizing radiation in doses of 0,14–4,7 Gy, as well as 18 non-exposed patients with organic mental disorders. Visual and morphometric assessments of MRIs have been done. Morphometry of MRI included analysis of contrast coefficients between brain structures and cerebral liquor system, sizes of lateral ventricles and the third ventricle, indices of lateral ventricles bodies, frontal horns of lateral ventricles and the third ventricle. Cortical atrophy of cerebral hemispheres and damage of neuronal pathways in the dominant hemisphere are the characteristic morphometric neuroimaging features of organic brain damage in remote period of exposure to ionizing radiation as a result of the Chernobyl accident. There was revealed the «dose–effect» relationship between the dose and the characteristic morphometric neuroimaging features of organic brain damage, starting with 0,3 Gy and increasing in proportion to the dose.
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