Radiation dose to the pancreas and risk of diabetes mellitus in childhood cancer survivors: a retrospective cohort study
Title: Radiation dose to the pancreas and risk of diabetes mellitus in childhood cancer survivors: a retrospective cohort study
Author: de Vathaire, Florent / El-Fayech, Chiraz / Ben Ayed, Faten Fedhila / Haddy, Nadia / Guibout, Catherine / Winter, David / Thomas-Teinturier, Cécile / (…) / Oberlin, Odile
Reference: The Lancet Oncology, 13 (10), p.1002-1010, Oct 2012
doi: 10.1016/S1470-2045(12)70323-6
Keywords: childhood cancer
Abstract: …We sent a questionnaire to 3468 survivors of a childhood cancer treated in eight centres in France and the UK between 1946 and 1985, of which 2520 were returned. Each self-declaration of diabetes was confirmed by contacting the patients’ medical doctors. We estimated the radiation dose received by the tail, head, and body of the pancreas and 185 other anatomical sites during each course of radiotherapy from 1990 to 1995 for each child after reconstruction of the conditions in which irradiation was delivered. We investigated the relation between radiation dose to the pancreas and the risk of a subsequent diabetes diagnosis….
…252·4) * Adjusted for age at cancer, calendar year at cancer, sex, chemotherapy…areas highly contaminated by the Chernobyl nuclear…study, in a cohort of childhood cancer survivors…
URL: http://www.sciencedirect.com/science/article/pii/S1470204512703236
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