RET oncogene amplification in thyroid cancer: Correlations with radiation-associated, high-grade malignancy, and genomic instability

Title: RET oncogene amplification in thyroid cancer: Correlations with radiation-associated, high-grade malignancy, and genomic instability

Author: Nakashima, Masahiro / Takamura, Noboru / Namba, Hiroyuki / Saenko, Vladimir A. / Suzuki, Keiji / Meirmanov, Serik / Hayashi, Tomayoshi / Sekine, Ichiro

Reference: International Congress Series, 1299, p.251-255, Feb 2007

doi: 10.1016/j.ics.2006.09.002

Keywords: Thyroid cancer; RET oncogene; Genomic instability; 53BP1; Radiation; Interphase FISH

Abstract: RET oncogene rearrangement is a well-known molecular alteration observed in papillary thyroid cancer (PTC). RET rearrangement is the commonest oncogenic alterations in Chernobyl-related PTC; nearly all to RET/PTC1 or RET/PTC3, resulting from paracentric inversion of chromosome 10. Other less common variants, usually forming as a result of interchromosomal translocation, occur in an extremely limited number of cases….

URL:http://www.sciencedirect.com/science/article/pii/S0531513106006182

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