Genetic effects of exposure to flora (plant population) under circumstances with radioactive contamination

Author: KAL’CHENKO V.A.
Reference: Moscow, 1998
Keywords: genetic effects, plant, contamination of environment

Abstract: Our aim was to evaluate genetic processes in plant populations under radioactive contamination resulting from a large-scale accident at a nuclear industry.

URL:http://earthpapers.net/vliyanie-ioniziruyuschey-radiatsii-na-uroven-polimorfizma-dnk-v-raznyh-tkanyah-u-potomstva-obluchennyh-myshey

Irradiation and second cancers. The thyroid as a case in point

Title: Irradiation and second cancers. The thyroid as a case in point
Author: Schlumberger, Martin / Cailleux, Anne-Françoise / Suarez, Horacio G / de Vathaire, Florent

Reference: Comptes Rendus de l’Académie des Sciences – Series III – Sciences de la Vie, 322 (2-3), p.205-213, Feb 1999

doi: 10.1016/S0764-4469(99)80045-6

Keywords: irradiation; thyroid tumours; Chernobyl; RET rearrangements

Abstract: …Radioiodine 131 (1311) used for medical purposes has almost no tumourigenic effect on the adult thyroid gland. The consequences of the Chernobyl accident have clearly shown that the risk of thyroid cancer after exposure to 1311 in childhood is important, and that such exposure should be prevented by potassium iodine prophylaxis. RET/PTC rearrangements are found in 60–80 % of papillary carcinomas and in 45 % of adenomas occurring after radiation exposure. They are found in 5–15 % of papillary carcinoma and in no follicular adenomas that occurred in the absence of radiation exposure.

URL:http://www.sciencedirect.com/science/article/pii/S0764446999800456

Gene rearrangements in thyroid carcinomas after irradiation during childhood: lessons from the Chernobyl reactor accident

Title: Gene rearrangements in thyroid carcinomas after irradiation during childhood: lessons from the Chernobyl reactor accident

Author: Rabes, Hartmut M

Reference: International Congress Series, 1234, p.193-200, May 2002

doi: 10.1016/S0531-5131(01)00608-2

Keywords: Papillary thyroid carcinoma; Gene rearrangement; DNA breakpoints; Irradiation; RET

Abstract: Papillary thyroid carcinomas (PTC) developed with a high incidence in children and young adults who had been exposed to radioactive fallout in contaminated regions of Belarus after the Chernobyl reactor accident. They are informative for a molecular genetic analysis of radiation-induced PTC. In contrast to spontaneous PTC, a high prevalence of gene aberrations was found with rearrangements of the receptor tyrosine kinase gene RET in the majority of cases and a few NTRK1 rearrangements. In the rearranged form of RET, the transmembrane and extracellular parts are replaced by regulatory units of other genes….

URL: http://www.sciencedirect.com/science/article/pii/S0531513101006082

Differences in the expression profiles of normal contralateral tissues of papillary thyroid cancer patients exposed and not exposed to the Chernobyl fallout

Title: Differences in the expression profiles of normal contralateral tissues of papillary thyroid cancer patients exposed and not exposed to the Chernobyl fallout

Author: Dumont, J.-E. / Dom, G. / Tarabichi, M. / Jarzab, B. / Unger, K. / Thomas, G. / Detours, V. / Maenhaut, C.

Reference: Médecine Nucléaire, 35 (5), p.327-328, May 2011

doi: 10.1016/j.mednuc.2011.02.008

Keywords: Irradiation; Thyroid cancer;Predisposition

Abstract: .individuals develop cancer. This might…hypotheses. Papillary thyroid cancer (PTCs) incidence…children after the Chernobyl accident, providing…childhood to the Chernobyl 131I fallout…rate in normal thyroid could predispose to cancer after irradiation…

URL: http://www.sciencedirect.com/science/article/pii/S092812581100074X