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タグ「乳癌」

西ベラルーシの乳癌および卵巣がんファミリーのBRCA 1 遺伝子の創始者変異

Title: Founder mutations in the BRCA1 gene in west Belarusian breast-ovarian cancer families

Author: O Oszurek, B Gorski, J Gronwald, Z Prosolow, K Uglanica, A Murinow, I Bobko, O Downar, M Zlobicz, D Norik, T Byrski, A Jakubowska, J Lubinski

Reference: Clinical Genetics, Volume 60, Issue 6, pages 470–471, December 2001

DOI: 10.1034/j.1399-0004.2001.600611.x

Keywords:BRCA1, Belarus, breast cancer, ovarian cancer

Abstract: Germline mutation at eight human minisatellite loci has been studied among families from rural areas of the Kiev and Zhitomir regions of Ukraine, which were heavily contaminated by radionuclides after the Chernobyl accident. The control and exposed groups were composed of families containing children conceived before and after the Chernobyl accident, respectively. The groups were matched by ethnicity, maternal age, parental occupation, and smoking habits, and they differed only slightly by paternal age. A statistically significant 1.6-fold increase in mutation rate was found in the germline of exposed fathers, whereas the maternal germline mutation rate in the exposed families was not elevated. These data, together with the results of our previous analysis of the exposed families from Belarus, suggest that the elevated minisatellite mutation rate can be attributed to post-Chernobyl radioactive exposure. The mechanisms of mutation induction at human minisatellite loci are discussed.

URL: http://onlinelibrary.wiley.com/doi/10.1034/j.1399-0004.2001.600611.x/abstract

ベラルーシの乳癌および卵巣癌患者におけるBRCA1の創始者突然変異の高頻度および対立遺伝子特有の違い

タイトル:ベラルーシの乳癌および卵巣癌患者におけるBRCA1の創始者突然変異の高頻度および対立遺伝子特有の違い

著者:ボグダノヴァN. V., アンドネンコヴァN. N., ロゴフY. I., カルステンスJ. H., ヒレマンスP., ドークT.

典拠:Clinical Genetics、78巻、4号、364-372頁、2010年10月。

DOI: 10.1111/j.1399-0004.2010.01473.x

キーワード:BRCA1、乳癌、創始者突然変異、遺伝的感受性、卵巣癌、放射線、ベラルーシ

概要:ベラルーシで0は乳癌と卵巣癌は一般的な悪性腫瘍であり、それぞれ年に約3500件、800件発症する。乳癌については、その発症率と発症年齢はチェルノブイリ事故から異なる影響を受けた地域毎に大きく異なっていることが分かった。

URL:http://onlinelibrary.wiley.com/doi/10.1111/j.1399-0004.2010.01473.x/abstract

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