Microsatellite mutations show no increases in the children of the Chernobyl liquidators

Title: Microsatellite mutations show no increases in the children of the Chernobyl liquidators

Author: Furitsu, Katsumi; Ryo, Haruko; Yeliseeva, Klaudiya G.; Thuy, Le Thi Thanh; Kawabata, Hiroaki; Krupnova, Evelina V.; Trusova, Valentina D.; Rzheutsky, Valery A.; Nakajima, Hiroo; Kartel, Nikolai; Nomura, Taisei.

Reference: Mutation Research/Genetic Toxicology & Environmental Mutagenesis. Mar2005, Vol. 581 Issue 1/2, p69-82. 14p.

DOI: 10.1016/j.mrgentox.2004.11.002.

Keywords: Radiation-induced germline microsatellite mutations; Liquidator; Chernobyl; Ionizing radiation

Abstract: We performed a study on Belarusian “liquidators”, exploring whether increase in the frequencies of germline mutations at microsatellite loci could be found in their progeny. The liquidators, mostly young males, were those involved (during 1986 and 1987) in clean-up operations in the radioactively contaminated area following the Chernobyl nuclear power plant accident in 1986. Many liquidators fathered children during the clean-up period and after the work had been terminated. The numbers of families studied were 64 (liquidators) and 66 (controls). A total of 72 loci (31 autosomal, one X-linked and 40 Y-linked) were used. DNA was isolated from peripheral blood lymphocytes and the microsatellite loci were amplified by the polymerase chain reaction with fluorescence-labelled primers. Mutations were detected as variations in the length of the loci.

URL: http://www.sciencedirect.com/science/article/pii/S1383571804003006

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