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Increased incidence of malignancies in Sweden after the Chernobyl accident-a promoting effect?

Title: Increased incidence of malignancies in Sweden after the Chernobyl accident-a promoting effect?

Author: Martin Tondel, Peter Lindgren,1 Peter Hjalmarsson,Lennart Hardell, Bodil Persson4

Reference: AMERICAN JOURNAL OF INDUSTRIAL MEDICINE 49:159–168 (2006) [PDF-140K]Mar 2011

Keywords: caesium-137; ionising radiation; nuclear power; low dose; epidemiology; environment; background radiation; cancer; GIS; cohort

Abstract: After the Chernobyl accident in 1986, as much as 5% of the released caesium-137 was deposited in Sweden due to a heavy rainfall 2 days after the event. A study of increased incidence of malignancies was initiated after the accident.

URL: http://www.ippnw.org/pdf/chernobyl-increased-incidence-malignancies-sweden.pdf

Estimation of thyroid doses and health risks resulting from the intake of radioactive iodine in foods and drinking water by the citizens of Tokyo after the Fukushima nuclear accident

Title: Estimation of thyroid doses and health risks resulting from the intake of radioactive iodine in foods and drinking water by the citizens of Tokyo after the Fukushima nuclear accident
Author: Murakami, Michio / Oki, Taikan

Reference: Chemosphere, 87 (11), p.1355-1360, Jun 2012

doi: 10.1016/j.chemosphere.2012.02.028

Keywords: Cancer risk; Fukushima nuclear power plant accident; Ingestion dose; Internal exposure; I-131; Radionuclides

Abstract: …carcinogen, causing thyroid cancer in particular, the…from fallout from the Chernobyl accident of 1986 had…dose-related increase in thyroid cancer ( Cardis and Hatch…Health effects of the Chernobyl accident for most individuals…

URL: http://www.sciencedirect.com/science/article/pii/S0045653512002184

The Evolution of Biomarkers in Thyroid Cancer From Mass Screening to a Personalized Biosignature

Title: The Evolution of Biomarkers in Thyroid Cancer From Mass Screening to a Personalized Biosignature

Author: Raymon H. Grogan †, Elliot J. Mitmaker † and Orlo H. Clark *

Reference: Cancers 2010, 2, 885-912; doi: [PDF-255K]Jun 2011

doi: 10.3390/cancers2020885

Keywords: thyroid cancer; biomarker; biological marker; molecular marker; tumor marker; molecular pathways; epigenetics;  serum based biomarkers;  Genomics;proteomics

Abstract: …in papillary thyroid cancer. The RET/PTC 1 and…been found in papillary thyroid cancers after radiation…nuclear accidents, such as Chernobyl, and from exposure to…in childhood papillary thyroid cancer. A high frequency of..

URL: http://www.mdpi.com/2072-6694/2/2/885/pdf

Approach to and Treatment of Differentiated Thyroid Carcinoma

Title: Approach to and Treatment of Differentiated Thyroid Carcinoma

Author: Pacini, Furio / Castagna, Maria Grazia
Reference: Medical Clinics of North America, 96 (2), p.369-383, Mar 2012

doi: 10.1016/j.mcna.2012.01.002

Keywords: Thyroglobulin; rhTSH; 131I whole-body scan; Radioiodine therapy

Abstract: …familial nonmedullary thyroid carcinoma (FNMTC…environmental risk factor for thyroid carcinoma is exposure…the explosion of the Chernobyl nuclear reactor in 1986…incidence of malignant thyroid tumors (80 times more…development of thyroid cancer. 32–34 Presentation…

URL: http://www.sciencedirect.com/science/article/pii/S002571251200003X

Influence of the Chernobyl accident on thyroid function and non-tumor morbidity

Title: Influence of the Chernobyl accident on thyroid function and non-tumor morbidity

Author: Cheban, Anatoly K

Reference: International Congress Series, 1234, p.245-252, May 2002

doi: 10.1016/S0531-5131(01)00614-8

Keywords: Chernobyl disaster; Ionizing radiation; Thyroid gland; Nonstochastic effects; Chronic thyroiditis; Hypothyroidism

Abstract: We summarized the results of studies on the post-Chernobyl thyroid function among evacuees from the estrangement zone, “liquidators” of 1986 period and people living for a long time (“self-settlers”) and working in the 30-km zone. Studies were conducted using standardized procedures including clinical examination, thyroid ultrasound examination, and assay of serum thyroid hormones and anti-thyroid antibodies content. Both of the radiation exposure modes, e.g., short-term, prolonged, combined, and the radiation dose were taken into account in the analysis of the results. The data analyzed indicated that the thyroid function has been subjected to alteration through the post-Chernobyl period and that nonstochastic radiation effects on the thyroid function, i.e., chronic thyroiditis and hypothyroidism, have been emerging though gradually.

URL: http://www.sciencedirect.com/science/article/pii/S0531513101006148

Histological characterization of papillary thyroid carcinoma in children, adolescents and young adults in Russia after the Chernobyl accident

Title: Histological characterization of papillary thyroid carcinoma in children, adolescents and young adults in Russia after the Chernobyl accident

Author: Lushnikov, Eugeny F / Abrossimov, Alexandre Yu

Reference: International Congress Series, 1234, p.239-244, May 2002

doi: 10.1016/S0531-5131(01)00613-6

Keywords: Chernobyl; Thyroid carcinoma; Histology

Abstract: The purpose of the study was to analyze the histological features of post-Chernobyl papillary thyroid carcinoma (PTC) that occurred in children, adolescents and young adults living in radionuclide-contaminated territories of the Russian Federation. We reviewed the histological sections of thyroid carcinoma in 123 patients (39 males and 84 females) aged 0–16 years at the time of accident from Bryansk, Kaluga, Oriol and Tula regions of Russia….

URL:http://www.sciencedirect.com/science/article/pii/S0531513101006136

Re-evaluation of thyroid doses in Russia after the Chernobyl accident

Title: Re-evaluation of thyroid doses in Russia after the Chernobyl accident

Author: Stepanenko, Valery F / Gavrilin, Yuri I / Khrouch, Valery T / Shinkarev, Sergey M / Hoshi, Masaharu / Iaskova, Elena K / Kondrashov, Alexey E / (…) / Rivkind, Nikolay B

Reference: International Congress Series, 1234, p.321-328, May 2002

doi: 10.1016/S0531-5131(01)00621-5

Keywords: Chernobyl accident; I-131; Thyroid dose; Individual dosimetry

Abstract: Immediately after the Chernobyl accident, the team of Medical Radiological Research Center (MRRC) specialists carried out wide-scale measurements of iodine-131 content in the thyroid gland of 27 887 inhabitants of the Kaluga region. This initial information was presented only as official reports to governmental structures. Similar work was done by local specialists for 1441 inhabitants of the Bryansk region. The data of direct measurements provided us the basis for further individual thyroid dose estimations, where we exploited the developed model and personal interviews.This paper presents the results of updated dose evaluations, including the additional factors, such as dynamics of fallout and data on the pasture period…

URL: http://www.sciencedirect.com/science/article/pii/S0531513101006215

131 I Dose-Dependent Thyroid Autoimmune Disorders in Children Living around Chernobyl

Title: 131 I Dose-Dependent Thyroid Autoimmune Disorders in Children Living around Chernobyl
Author: Vykhovanets, Eugene V. / Chernyshov, Victor P. / Slukvin, Igor I. / Antipkin, Yury G. / Vasyuk, Alexander N. / Klimenko, Helen F. / Strauss, Kenneth W

Reference: Clinical Immunology and Immunopathology, 84 (3), p.251-259, Sep 1997

doi: 10.1006/clin.1997.4379

Abstract: We assessed the major lymphocyte subsets in the peripheral blood, thyroid ultrasonography, levels of serum autoantibodies to thyroglobulin (AbTg), thyroid hormones, and thyroid-stimulating hormone (TSH) in 53 children without any chronic diseases living continuously around Chernobyl. The subjects ranged in age from 7 to 14 years and had different doses of131I to their thyroid. Healthy children living on noncontaminated areas were assessed as controls….

URL: http://www.sciencedirect.com/science/article/pii/S0090122997943798

Thyroid cancer in children in Belarus: ascertainment bias?

Title: Thyroid cancer in children in Belarus: ascertainment bias?

Author: Averkin, JuriI. / Abelin, Theodor / Bleuer, JürgP.
Reference: The Lancet, 346 (8984), p.1223-1224, Nov 1995

doi: 10.1016/S0140-6736(95)92924-X

Abstract: …of childhood thyroid cancer after the Chernobyl accident…Belarus after the Chernobyl accident were Figure: Thyroid cancer in Belarus…Baverstock KF. Thyroid cancer in children in Belarus after Chernobyl Wld Hlth Statist…

URL: http://www.sciencedirect.com/science/article/pii/S014067369592924X

Teratogen Update: Radiation and Chernobyl FRANK P. CASTRONOVO JR.*…

Title: Teratogen Update: Radiation and Chernobyl FRANK P. CASTRONOVO JR.*…
Author: FRANK P. CASTRONOVO JR.*

Reference: [PDF-54K]Feb 2008

Abstract: The 1986 nuclear reactor accident at Chernobyl caused nonuniform radiocontamination of air and land, primarily within regions of the former Soviet Union and Western Europe. .. Radioiodine (I-131) caused thyroid cancer in young children in portions of Belarus, the Ukraine, and Russia. It is not known but very possible that I-131 fetal thyroid exposure contributed to this observation… Occasional positive teratogenic studies in less contaminated regions of Western Europe are suspect because of the low radiation doses received. There is no substantive proof regarding radiation-induced teratogenic effects from the Chernobyl accident. Teratology 60:100–106, 1999.

URL: http://teratology.org/updates/60pg100.pdf

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