Title: Molecular epidemiology of childhood thyroid cancer around Chernobyl
Author: Yamashita, Shunichi / Shibata, Yoshisada / Namba, Hiroyuki / Takamura, Noboru / Saenko, Vladimir,
Reference: International Congress Series, 1236, p.201-205, Jul 2002
doi: 10.1016/S0531-5131(01)00855-X
Keywords: Chernobyl; Screening ; Thyroid cancer; Gene rearrangement; Signal transduction
Abstract: …The comparative study of thyroid diseases demonstrates the likelihood of short-lived radioactive iodine on thyroid cancer in the children born before the Chernobyl accident. Next, at the standpoint of recent molecular analysis of thyroid carcinogenesis, many reports now indicate evidence of a high incidence of ret/PTC gene rearrangement in childhood thyroid cancer tissues. Besides ret/PTC gene rearrangement, the disturbance of the response of intracellular signal transduction to radiation exposure is also important in thyroid cells, and results demonstrate that radiation exposure could cause abnormal thyroid cell proliferation specifically through constitutive activation of intracellular target molecules via membrane lipid breakdown, and subsequently disturb the apoptosis-prone pathway. …Therefore, the late effect of radiation, even in the lower dose on the human thyroid glands, should be monitored carefully for the radiation-sensitive vulnerable group for a longer period, especially around Chernobyl.
URL: http://www.sciencedirect.com/science/article/pii/S053151310100855X
Title: Thyroid cancer among children and adolescents of Belarus exposed due to the Chernobyl accident: dose and risk assessment
Author: Kenigsberg, Jacov E / Buglova, Elena E / Kruk, Julianna E / Golovneva, Alla L
Reference: International Congress Series, 1234, p.293-300, May 2002
doi: 10.1016/S0531-5131(01)00618-5
Keywords: Thyroid cancer; Chernobyl accident; Assessment
Abstract: …Number of thyroid cancer cases after the Chernobyl accident…consequences of the Chernobyl accident among…radiation-induced thyroid cancer. There is…accident at the Chernobyl Nuclear Power Plant, thyroid cancer incidence…
URL: http://scirus.com/srsapp/search?q=chernobyl+(thyroid+cancer)&t=all&fdt=0&tdt=2014&drill=yes&sort=0&p=30&nff=pdf
Title: : Radioiodine-induced thyroid cancer: Studies in the aftermath of the accident at Chernobyl
Author Robbins, Jacob / Schneider, Arthur B
Reference: Trends in Endocrinology & Metabolism, 9 (3), p.87-94, Apr 1998
doi: 10.1016/S1043-2760(98)00024-1
Keywords: radiation; thyroid cancer; thyroid oncogenes; radioiodine; Chernobyl cancer
Abstract: While a great deal is known about the relationship between external radiation exposure and thyroid cancer, much less is known about the oncogenic effects of internal radiation exposure from isotopes of iodine. The accident at the Chernobyl nuclear power plant released massive quantities of radioiodine isotopes into the atmosphere. The large number of ensuing thyroid cancers in exposed children leaves little doubt that these malignancies have occurred as a result of the accident. However, carefully planned epidemiological studies are needed to confirm that these are due predominantly to I-131 exposure, to determine the dose-response relationship, to monitor for continuing effects and to evaluate other contributing factors. Preliminary evidence indicates that there is a distinct pattern of somatic genetic changes in the thyroid cancers from the Chernobyl area.
URL: http://www.sciencedirect.com/science/article/pii/S1043276098000241
Title: Ten-year Chernobyl aid programmes of the Otto Hug Strahleninstitut-MHM: treatment and research projects on thyroid cancer in Belarus
Author: Lengfelder, Edmund / Demidchik, Evgueni P. / Demidchik, Yuri E. / Sidorov, Yury D. / Gedrevich, Zigmund E. / Birukova, Ludmila W. / Gamolina, Larisa I. / (…) / Frenzel, Christine
Reference: International Congress Series, 1234, p.201-204, May 2002
doi: 10.1016/S0531-5131(01)00609-4
Keywords: Chernobyl; Thyroid cancer; Thyroid pathology; Medical care; Tissue bank
Abstract: The unexpected serious increase in the incidence of thyroid cancer following the reactor accident in Chernobyl led to considerable research efforts from abroad and the support of Belarus in order to mitigate these health problems. In 1991, the Otto Hug Strahleninstitut-MHM (Otto Hug Radiation Institute), a German non-governmental medical–scientific charity organization, started several long-term aid programmes and treatment and research projects on thyroid cancer and other diseases of this organ. Since 1993, the project “Thyroid Center Gomel” had more than 70 000 patients from this region for the diagnosis and treatment of thyroid diseases including cancer. …More than 6500 thyroid tumours were diagnosed, preparing over 30 000 pathological slides. In 1997, the project of “Radioiodine Therapy” started in Gomel, giving treatment to more than 450 patients since that time. …
URL:http://www.sciencedirect.com/science/article/pii/S0531513101006094
Title: Joint Belarus/Russia/EU/IARC/SMFH case–control studies of thyroid cancer in young people following the Chernobyl accident
Author: Cardis, Elisabeth / Ivanov, Victor K / Kesminiene, Ausrele / Malakhova, Irina V / Shibata, Yoshisada / Tenet, Vanessa / on behalf of the joint study group,
Reference: International Congress Series, 1234, p.105-113, May 2002
doi: 10.1016/S0531-5131(01)00600-8
Keywords: Thyroid cancer; Radiation risk; Risk modifiers; Iodine deficiency; Genetic predisposition; Children; Chernobyl
Abstract: In 1996, following several years of collaborative international studies of the consequences of the Chernobyl accident, a number of groups proposed to carry out case–control studies of thyroid cancer among young people in contaminated territories of Belarus and Russia. … The collaboration has resulted in the collection of one of the largest sources of data on thyroid cancer risk in children, adolescents and young adults exposed to ionising radiation. Results from this work are likely to have important implications for radiation protection in general, as well as for public health actions among exposed populations in the CIS.
URL: http://www.sciencedirect.com/science/article/pii/S0531513101006008
Title: Thyroid cancer in children and young adults in the North of England. Is increasing incidence related to the Chernobyl accident?
Author: Cotterill, S.J. / Pearce, M.S. / Parker, L.
Reference: European Journal of Cancer, 37 (8), p.1020-1026, May 2001
doi: 10.1016/S0959-8049(00)00449-4
Keywords: Thyroid neoplasms; Childhood cancer; Young adults; Iodine radioisotopes; Nuclear accidents
Abstract: Population-based data on thyroid carcinomas was obtained from the Northern Region Young Person’s Malignant Disease Registry to analyse the incidence of thyroid cancers in young people (<25 years) in the North of England for the period 1968 and 1997 and to assess if changes in incidence were consistent with the spatial and temporal distribution of the fallout from the Chernobyl nuclear accident. We compared incidence rates for differentiated (papillary or follicular) thyroid carcinomas 1968–1986 with those for 1987–1997. …These temporal and spatial changes in incidence are consistent with a causal association with the Chernobyl accident although a greater effect in the younger rather than the older age group would have been anticipated. However, factors including improvements in ascertainment and earlier detection of tumours may also have contributed to the increasing incidence. …
URL: http://www.sciencedirect.com/science/article/pii/S0959804900004494
Title: Thyroid cancer following Chernobyl
Author: Stiller, C.A.
Reference: European Journal of Cancer, 37 (8), p.945-947, May 2001
doi: 10.1016/S0959-8049(01)00072-7
Keywords:
Abstract: …radiation exposure from Chernobyl. Young people with thyroid cancer in the regions of…incidence rates for thyroid cancer post-Chernobyl among young people…Any increase in thyroid cancer risk related to Chernobyl would be expected to be…
URL: http://www.sciencedirect.com/science/article/pii/S0959804901000727
Title: The Chernobyl Tissue Bank, an international collaboration to investigate the relationship between the exposure to radiation in childhood and thyroid cancer
Author: Thomas, Geraldine A. / Tuttle, Michael / on behalf of the Collaborative Management Committee, Scientific Project Panel and Pathology and Blood Panels of the CTB,
Reference: International Congress Series, 1299, p.167-173, Feb 2007
doi: 10.1016/j.ics.2006.10.015
Keywords: Chernobyl; Tissue bank; Molecular biology
Abstract: The only unequivocal radiological effect of the Chernobyl accident on human health is the increase in thyroid cancer in those exposed in childhood. In response to the scientific interest in studying the molecular biology of thyroid cancer post-Chernobyl, the Chernobyl Tissue Bank (CTB: www.chernobyltissuebank.com) was established. The project is supported by the governments of Ukraine and Russia, and financially supported (US$3 M) by the European Commission, the National Cancer Institute of the USA, the Sasakawa Memorial Health Foundation of Japan and the World Health Organization. Full informed consent is obtained from donors; each case is subject to pathological review by an international panel. Aliquots of extracted nucleic acid (RNA and DNA from tissue, DNA from blood) serum are made available to researchers worldwide. …
URL: http://www.sciencedirect.com/science/article/pii/S0531513106005930
Title: Thyroid cancer in children and young adults in the North of England. Is increasing incidence related to the Chernobyl accident?
Author: Cotterill, S.J. / Pearce, M.S. / Parker, L.
Reference: European Journal of Cancer, 37 (8), p.1020-1026, May 2001
doi: 10.1016/S0959-8049(00)00449-4
Keywords: Thyroid neoplasms; Childhood cancer; Young adults; Iodine radioisotopes; Nuclear
Abstract: Population-based data on thyroid carcinomas was obtained from the Northern Region Young Person’s Malignant Disease Registry to analyse the incidence of thyroid cancers in young people (<25 years) in the North of England for the period 1968 and 1997 and to assess if changes in incidence were consistent with the spatial and temporal distribution of the fallout from the Chernobyl nuclear accident. We compared incidence rates for differentiated (papillary or follicular) thyroid carcinomas 1968–1986 with those for 1987–1997. …
URL: http://www.sciencedirect.com/science/article/pii/S0959804900004494
Title:Results of radioactive iodine treatment in children from Belarus with advanced stages of thyroid cancer after the Chernobyl accident,
Author: Reiners, Christoph / Biko, Johannes / Demidchik, Evgueni P / Demidchik, Yuri E / Drozd, Valentina M
Reference: International Congress Series, 1234, p.205-214, May 2002
doi: 10.1016/S0531-5131(01)00610-0
Keywords: Childhood thyroid cancer; Chernobyl; Radioiodine treatment
Abstract: Exposure of the thyroid to ionising radiation leads to an increased cancer risk. Whereas the average excess relative risk after external exposure amounts to approximately 8 per Gy, this relative risk is lower by a factor of 2 after exposure to radioiodine. The risk is greatest in newborns and small children below age of 5, intermediate in adolescents and questionable in adults. Papillary thyroid cancer with a relative incidence of approximately 80% per se is typical for thyroid cancer in childhood and adolescence; however, after exposure to radioiodine, this relative frequency is increased close to 100%. Bilateral involvement, multicentric growth and cancer not limited to the thyroid gland seem to be characteristic for radiation-induced thyroid cancer. Up to now, approximately 1500 cases of thyroid cancer in children below age of 15 have been diagnosed between 1990 and 2000 after the Chernobyl accident in Belarus, the Ukraine and Russia….
URL: http://www.sciencedirect.com/science/article/pii/S0531513101006100
