Post-radiation syndrome as a NO/ONOO(-) cycle, chronic fatigue syndrome-like disease

Author: Pall M.L.

Reference: Med. Hypotheses. — 2008. — Vol. 71, № 4. — P. 537–541.

Keywords: CFS, oxide/peroxynitrite (NO/ONOO-) cycle

Abstract: Post-radiation syndrome is proposed to be chronic fatigue syndrome (CFS) or a chronic fatigue syndrome-like illness, initiated by exposure to ionizing radiation. This view is supported by the nitric oxide/peroxynitrite (NO/ONOO-) cycle mechanism, the putative etiologic mechanism for CFS and related illnesses. Ionizing radiation may initiate illness by increasing nitric oxide levels via increased activity of the transcription factor NF-kappaB and consequent increased synthesis of the inducible nitric oxide synthase. Two types of components of the nitric oxide/peroxynitrite cycle have been studied in post-radiation syndrome patients and shown to be elevated. The symptoms and signs of post-radiation syndrome and its chronicity are similar or identical to those of chronic fatigue syndrome and can be explained as being a consequence of nitric oxide/peroxynitrite cycle etiology. While the data available to test this view are limited, it provides for the first time a comprehensive explanation for post-radiation syndrome.

URL: http://www.ncbi.nlm.nih.gov/pubmed/18667279

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