タグ「Cardiovascular Disease (CDV)」
Title: Radiation induced cardiac valve disease in a man from Chernobyl
Author: Bose AS, Shetty V, Sadiq A, Shani J, Jacobowitz I.
Reference: J Am Soc Echocardiogr. 2009 Aug;22(8):973.e1-3.
doi: 10.1016/j.echo.2009.03.027.
Keywords: Radiation-induced valve disease; Aortic stenosis; Mitral regurgitation
Abstract: A young man presented with a new heart murmur. History revealed that the patient was from Ukraine, which was affected by the Chernobyl nuclear plant explosion in 1986. Physical examination revealed murmurs of mitral regurgitation and aortic stenosis. Transesophageal echocardiography revealed severely calcified mitral and calcified tricuspid aortic valves with mitral and aortic regurgitation and aortic stenosis. Following valve replacement surgery, pathologic examination of the valves showed severe dystrophic calcifications and changes suggestive of a chronic inflammatory process such as radiation-induced valve disease. In the absence of another etiology explaining such severe valve disease in a young man, it can only be surmised that heavy radiation exposure from the nuclear plant caused this significant valve damage.
ＵＲＬ：http://www.ncbi.nlm.nih.gov/pubmed/19647162
Author: M.G. Bolotnikova, N.A. Koshurnikova, N.S. Komlevaet al.
Reference: Sci. Total. Environ. — 1994. — 142: — 29–31.
Keywords: cardiovascular disease, ischemic heart disease, cerebrovascular disease
Abstract: An epidemiologic retrospective study was conducted on the basis of a personnel registry, including 9373 male workers who had started to work at the radiochemical plant during the period from 1948 to 1972, inclusive. Male mortality from cardiovascular disease proved to be 271.1 cases in 100,000 persons/year on average. The age-standardized mortality amounted to 502.5 cases in 100,000 persons/year, which is significantly lower than that of the entire male population. Regarding the structure of mortality from cardiovascular diseases in the studied male groups, the mortality rate from ischemic heart disease (IHD) was 63.7% and that from cerebrovascular disease 21.5%, compared with 57% and 30%, respectively, for the general male population. Mortality from cardiovascular diseases is lower in the study groups than in the general public and does not depend on the external gamma-irradiation dose.
URL: http://www.ncbi.nlm.nih.gov/pubmed/8178133
Author: V.K. Ivanov, A.I. Gorski, M.A. Maksioutov et al.
Reference: Health Phys. — 2001. — Vol. 81, № 5. — P. 514–521.
Keywords: liquidator, malignant neoplasm, cardiovascular disease, injury
Abstract: This paper presents results of the analysis of mortality among Chernobyl accident emergency workers who are resident in Russia. The analysis is based on information for the cohort of emergency workers (males) from six regions of Russia including 65,905 persons with documented external doses in the range 0.005-03 Sv. These data were gathered during the period 1991 to 1998 and cover a total of 426,304 follow-up person-y. In this period, 4,995 deaths occurred in the cohort under study. The mortality analysis was performed for four groups of causes of death (ICD-9 codes): (1) malignant neoplasms (140-239); (2) cardiovascular diseases (390-459); (3) injuries, poisoning and violent deaths, (800-999); and (4) the remainder (other than the above). The standardized mortality rate for groups 1, 3, and 4 is less than unity and varies from 0.6 to 0.9. For group 2 (death from cardiovascular diseases) the standardized mortality rate conforms with the control within 95% confidence intervals. The control was the mortality rate (males) for the corresponding ages in Russia in general and the internal control, the spontaneous mortality among emergency workers, derived from the equation of the observed and expected number of cases in the followed up cohort. Dose response of mortality was studied. Statistically significant radiation risks were obtained for mortality from malignant neoplasms (515 cases) and cardiovascular diseases (1,728 cases). The values of the excess relative risk per unit dose (ERR Sv(-1)) for malignant neoplasms and cardiovascular diseases are estimated as 2.11 (1.31, 2.92 95% CI) and 0.54 (0.18,0.91 95% CI) (for external control), 2.04 (0.45, 4.31 95% CI) and 0.79 (0.07, 1.64 95% CI) (for internal control), respectively. The risk of death from all noncancer causes is close to zero and not statistically significant
URL: http://www.ncbi.nlm.nih.gov/pubmed/11669204
Author: McGale P., Darby S.C.
Reference: Radiat. Res. — 2005. — Vol. 163, № 3. — P. 247–257.
Keywords: circulatory system, atomic bomb survivors
Abstract: Recent analyses of mortality among atomic bomb survivors have suggested a linear dose–response relationship between ionizing radiation and diseases of the circulatory system for exposures in the range 0–4 Sv. If confirmed, this has substantial implications. We have therefore reviewed the published literature to see if other epidemiological data support this finding. Other studies allowing a comparison of the rates of circulatory disease in individuals drawn from the same population but exposed to ionizing radiation at different levels within the range 0–5 Gy or 0–5 Sv were identified through systematic literature searches. Twenty-six studies were identified. In some, disease rates among those exposed at different levels may have differed for reasons unrelated to radiation exposure, while many had low power to detect effects of the relevant magnitude. Among the remainder, one study found appreciable evidence that exposure to low-dose radiation was associated with circulatory diseases, but five others, all with appreciable power, did not. We conclude that the other epidemiological data do not at present provide clear evidence of a risk of circulatory diseases at doses of ionizing radiation in the range 0–4 Sv, as suggested by the atomic bomb survivors. Further evidence is needed to characterize the possible risk.
URL: http://www.bioone.org/doi/abs/10.1667/RR3314
Editors: A. Serdiuk, V. Bebeshko, D. Bazyka, S. Yamashita.
Reference: Kyiv: DIA, 2011. ― 648 pp.
Abstract: A comprehensive overview on the diverse aftermaths (health effects) of the Chernobyl accident. The subjects include acute radiation syndrome, leukemia, solid cancers, cytogenetic effects, immunology, medico-demographic issues etc.
URL:http://www-sdc.med.nagasaki-u.ac.jp/gcoe/activities/publication/20110829_e.html
Little MP, Tawn EJ, Tzoulaki I, Wakeford R, Hildebrandt G, Paris F, Tapio S, Elliott P.
URL: http://www.ncbi.nlm.nih.gov/pubmed/18159955
Title: Expert evaluation of sudden death and suicide
Author: Makarov, Vladimir Mikhailovich
Reference: Ulyanovsk, 2005
Keywords: anatomical pathology, sudden death, Cardiovascular Disease (CDV), suicide
Abstract: Objective: on the basis of comprehensive medical-ecological and medical-social, morphological, forensic research to analyze the sudden death from cardiovascular disease in the region, adjacent to the polygon after the cessation of testing and to determine the pattern of suicides in different regions.
URL:http://www.dissercat.com/content/ekspertnaya-otsenka-vnezapnoi-smerti-i-suitsidov
Title: The Chernobyl Accident — An Epidemiological Perspective
Author: Cardis, E. / Hatch, M.
Reference: Clinical Oncology, 23 (4), p.251-260, May 2011
doi: 10.1016/j.clon.2011.01.510
Keywords: Cancer; cataracts; cardiovascular diseases; Chernobyl accident; radiation; thyroid cancer
Abstract: Twenty-five years have passed since radioactive releases from the Chernobyl nuclear accident led to the exposure of millions of people in Europe. Studies of affected populations have provided important new data on the links between radiation and cancer—particularly the risk of thyroid tumours from exposure to iodine isotopes—that are important not only for a fuller scientific understanding of radiation effects, but also for radiation protection. It is now well documented that children and adolescents exposed to radioiodines from Chernobyl fallout have a sizeable dose-related increase in thyroid cancer, with the risk greatest in those youngest at exposure and with a suggestion that deficiency in stable iodine may increase the risk….
URL: http://www.sciencedirect.com/science/article/pii/S0936655511005425
