A screening study of thyroid cancer and other thyroid diseases among individuals exposed in utero to iodine-131 from Chernobyl fallout (English)
M. Hatch, A. Brenner, T. Bogdanova et al.
タグ「childhood thyroid cancer」
Chromosomal imbalances in post-Chernobyl thyroid tumors.
Title: : Chromosomal imbalances in post-Chernobyl thyroid tumors.
Author: Richter, H., Braselmann, H., Hieber, L., Thomas, G.*, Bogdanova, T.*
Reference: Thyroid 14, 1061-1064 (2004)
Keywords: childhood thyroid tumors
Abstract: Tissue samples from 60 post-Chernobyl childhood thyroid tumors have been investigated. We used comparative genomic hybridization (CGH) to detect chromosomal gains and losses within the tumor DNA. This is the first CGH study on childhood thyroid tumors. The post-Chernobyl tumors showed chromosomal imbalances in 30% of tumors. The most frequent DNA copy number changes in post-Chernobyl tumors involved chromosomes 2, 7q11.2-21, 13q21-22, 21 (DNA gains), and chromosomes 16p/q, 20q, 22q (DNA losses). Some of these specific alterations detected in post-Chernobyl thyroid tumors (deletions on chromosomes 16p/q and 22q) have previously been reported in thyroid tumors as associated with an aggressive biologic behavior and may therefore also account for the more aggressive phenotype of papillary thyroid carcinoma (PTC) found in post- Chernobyl tumors. Eighteen percent of post-Chernobyl PTC that exhibit RET rearrangements also showed chromosomal imbalances indicating that either additional genetic events are involved in this subset of tumors, or that intratumoral genetic heterogeneity exists in these tumors, suggesting a oligoclonal pattern to tumor development.
THYROID EFFECTS
Title: SPECIAL REPORTS Report by Prof. E.D. Williams, Cambridge University,… THYROID EFFECTS
Author: E.D. Williams, A. Pinchera, D. Becker, . E.P. Demidchik, S. Nagataki, N.D. Tronko,
Reference: [PDF-73K]Jul 2007 IAEA BULLETIN, 3/1996
Keywords:
Abstract: …Ukraine close to Chernobyl, received the…for childhood thyroid cancer in Gomel during…cally confirmed thyroid cancers in children…Ukraine since the Chernobyl acci- dent…cases of childhood thyroid cancer is needed. The…
URL: http://www.iaea.org/Publications/Magazines/Bulletin/Bull383/38305893132.pdf
Time trends of thyroid cancer incidence in Belarus after the Chernobyl accident.
Title: Time trends of thyroid cancer incidence in Belarus after the Chernobyl accident.
Author: Heidenreich WF, Kenigsberg J, Jacob P, Buglova E, Goulko G, Paretzke HG, Demidchik EP, Golovneva A.
Reference: 1999.Radiation Research Society Radiat Res 151:617-25.
Keywords:childhood thyroid cancer,Belarus
Abstract: The rates of childhood thyroid cancer incidence observed in Belarus during the period 1986 to 1995 are described as a function of time after exposure, age at exposure, and sex. Conclusions are drawn for the excess absolute risk function. After a minimum latent period of about 3 years after exposure, this risk function has a linear increase with time for at least 6 years. After correction for the dependence of average doses on age, the radiation-induced absolute thyroid risk in Gomel is about a factor of 3 higher for children up to age 10 at exposure compared to older ones; this may be due in part to different case-collection quality. In addition, in the group up to 10 years at exposure, the thyroid of girls is more sensitive to radiation by a factor of about 1.5 than the thyroid of boys on an absolute scale. Risk estimates from external exposure are consistent with risk estimates from Gomel assuming that the increase in excess cases reaches a plateau soon.