RET/PTC and PAX8/PPARγ chromosomal rearrangements in post-Chernobyl thyroid cancer and their association with iodine-131 radiation dose and other characteristics.

Title: RET/PTC and PAX8/PPARγ chromosomal rearrangements in post-Chernobyl thyroid cancer and their association with iodine-131 radiation dose and other characteristics.

Author: Leeman-Neill RJ, Brenner AV, Little MP, Bogdanova TI, Hatch M, Zurnadzy LY, Mabuchi K, Tronko MD, Nikiforov YE.

Reference: Cancer. 2013 Feb 21.

doi: 10.1002/cncr.27893.

Keywords: RET/PTC, chromosomal rearrangements, PAX8/PPARγ, iodine-131

Abstract: These results provide the first demonstration of PAX8/PPARγ rearrangements in post-Chernobyl tumors and show different associations for point mutations and chromosomal rearrangements with (131) I dose and other factors. These data support the relationship between chromosomal rearrangements, but not point mutations, and (131) I exposure and point to a possible role of iodine deficiency in generation of RET/PTC rearrangements in these patients. Cancer 2013;. © 2013 American Cancer Society.

URL: http://www.ncbi.nlm.nih.gov/pubmed/23436219

Dose-Dependent Generation of RET/PTC in Human Thyroid Cells after in Vitro Exposure to -Radiation: A Model of Carcinogenic Chromosomal Rearrangement Induced by Ionizing Radiation.

Title: Dose-Dependent Generation of RET/PTC in Human Thyroid Cells after in Vitro Exposure to  -Radiation: A Model of Carcinogenic Chromosomal Rearrangement Induced by Ionizing Radiation.

Author: Christy M. Caudill, Zhaowen Zhu, Raffaele Ciampi, James R. Stringer, and Yuri E. Nikiforov

Departments of Pathology and Laboratory Medicine and Molecular Genetics, University

Reference: [PDF-201K]Jun 2009 The Journal of Clinical Endocrinology & Metabolism 90(4):2364–2369
doi: 10.1210/jc.2004-1811

Keywords:

Abstract: …countries (5, 6). The risk of thyroid cancer correlated with proximity to Chernobyl and thyroid dose and in some areas was found…radiation exposure. In this respect, thyroid cancer in children after the Chernobyl accident represents the most thoroughly…

URL: http://path.upmc.edu/people/ynlab/Publication%20PDFs/Zhu2005JournalofClincialEndoandMeta.pdf

Identification of Differentially Expressed Genes in Papillary Thyroid Carcinomas With and Without Rearrangements of the Tyrosine Kinase Receptors RET and/or NTRK1 1 1 This work was supported by a grant of the Deutsche Forschungsgemeinschaft to T.J.M. (MU 1221/5-1) and, in part, by a cash prize of the Lower Saxony Cancer Society (Förderpreis der Niedersächsischen Krebsgesellschaft) to P.B.M. and T.J.M.

Title: Identification of Differentially Expressed Genes in Papillary Thyroid Carcinomas With and Without Rearrangements of the Tyrosine Kinase Receptors RET and/or NTRK1 1 1
Author: Musholt, Thomas J. / Brehm, Christoph / Hanack, Julia / von Wasielewski, Reinhard / Musholt, Petra B.

Reference: Journal of Surgical Research, 131 (1), p.15-25, Mar 2006

doi: 10.1016/j.jss.2005.08.013

Keywords: papillary thyroid carcinoma; differential gene expression; chromosomal rearrangements; genetic alterations; mRNA differential display

Abstract:  This work was supported by a grant of the Deutsche Forschungsgemeinschaft to T.J.M. (MU 1221/5-1) and, in part, by a cash prize of the Lower Saxony Cancer Society (Förderpreis der Niedersächsischen Krebsgesellschaft) to P.B.M. and T.J.M….irradiation to the neck, Chernobyl-associated radio-iodine…phenotypes of the papillary thyroid tumors [ 5 ]. The…the tumors from the Chernobyl area [ 20, 21…receptors in papillary thyroid cancers as…with familial papillary cancer of the thyroid gland…

URL: http://www.sciencedirect.com/science/article/pii/S0022480405004580