Radioadaptive Response Following In Utero Low-Dose Irradiation

Title: Radioadaptive Response Following In Utero Low-Dose Irradiation

Author: Eric K. Howell, Sergey P. Gaschak, Kenneth D. W. Griffith and Brenda E. Rodgers

Reference: Radiation Research January 2013 : Vol. 179, Issue 1 (Jan 2013), pg(s) 29-37

DOI: 10.1667/RR3029.1

Keywords : In Utero, low-dose irradiation, DNA damage

Abstract: Acute radiation exposure is known to cause biological damage that leads to severe health effects. However, the effects and subsequent health implications of exposure to low doses of ionizing radiation are unclear. The purpose of this study was to investigate the effects of low-dose ionizing radiation exposures in utero. Pregnant laboratory mice (BALB/c) were exposed to low-dose Chernobyl radiation [10–13 mSv per day for 10 days] during organogenesis. The progeny were born and weaned in an uncontaminated laboratory, then were exposed to an acute radiation dose (2.4 Sv). Analysis of our end points (litter dynamics, DNA damage, bone marrow stem cell function, white blood cell counts and gene expression) suggests that a low-dose (100–130 mSv) in utero exposure to ionizing radiation is not deleterious to the offspring. Rather DNA damage, white blood cell levels, and gene expression results suggest a radioadaptive response was elicited for the in utero exposure with respect to the effects of the subsequent acute radiation exposure.

ＵＲＬ：http://www.bioone.org/doi/abs/10.1667/RR3029.1?prevSearch=chernobyl&searchHistoryKey=&queryHash=f7283fdb5d57d03bfdb1eb17f03c59a5

COMPARATIVE ANALYSIS OF MORBIDITY OF THROYD　DISEASES INCIDENCE IN DOPUBERTATNOM THE AGE OF THE CHILDREN OF THE KALUGA REGION

Title: COMPARATIVE ANALYSIS OF MORBIDITY OF THROYD　DISEASES INCIDENCE IN DOPUBERTATNOM THE AGE OF THE CHILDREN OF THE KALUGA REGION

Author: GOROBETS V.F.

Reference: Radiation and Lisk 2012,vol.21,No.4

Keywords: CHILDREN, IN UTERO EXPOSURE TO RADIATION, POLLUTION OF TERRITORIES BY IODINE-131 AND CAESIUM-137, IODINE SUPPLEMENTATION, THYROID DISEASES INCIDENCE

Abstract: Incidence of non-cancer thyroid diseases among prepubertal children exposed to radiation from Chernobyl in utero and resided in Zhizdra, Ulyanovo and Khvastovichi rayons of Kaluga oblast with different level of radioactive contamination was studied. It was shown that the rate of thyroid diseases incidence depended on natural iodine insufficiency in the areas of residence and radioiodine dose. The relative contribution of each of these factors can be estimated by difference between the incidence rate in exposed and unexposed children of the same age and the same area of residence.

URL: http://cyberleninka.ru/article/n/sravnitelnyy-analiz-zabolevaemosti-tireopatiyami-v-dopubertatnom-vozraste-detey-iz-kaluzhskoy-oblasti-obluchyonnyh-vnutriutrobno-za